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S. cerevisiae CMGE nucleating origin DNA melting

Electron Microscopy
3.3Å resolution
PDB entry 7qhs coloured by chain, front view.
PDB entry 7qhs coloured by chain, side view.
PDB entry 7qhs coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Assembly composition:
hetero pentadecamer (preferred)
Entry contents: 13 distinct polypeptide molecules
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentadecamer
Accessible surface area: 304458.36 Å2
Buried surface area: 96230.77 Å2
Dissociation area: 3,357.65 Å2
Dissociation energy (ΔGdiss): 10.12 kcal/mol
Dissociation entropy (TΔSdiss): 16.64 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-247590

Macromolecules

DNA replication licensing factor MCM2
Chain: 2
Length: 868 amino acids
Theoretical weight: 98.91 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Saccharomyces cerevisiae
InterPro:
DNA replication licensing factor MCM2 in PDB entry 7qhs, assembly 1, front view.
DNA replication licensing factor MCM2 in PDB entry 7qhs, assembly 1, side view.
DNA replication licensing factor MCM2 in PDB entry 7qhs, assembly 1, top view.
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DNA replication licensing factor MCM3
Chain: 3
Length: 1006 amino acids
Theoretical weight: 111.72 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P24279 (Residues: 1-971; Coverage: 100%)
Gene names: MCM3, SYGP-ORF23, YEL032W
Pfam:
InterPro:
DNA replication licensing factor MCM3 in PDB entry 7qhs, assembly 1, front view.
DNA replication licensing factor MCM3 in PDB entry 7qhs, assembly 1, side view.
DNA replication licensing factor MCM3 in PDB entry 7qhs, assembly 1, top view.
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DNA replication licensing factor MCM4
Chain: 4
Length: 933 amino acids
Theoretical weight: 105.14 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P30665 (Residues: 1-933; Coverage: 100%)
Gene names: CDC54, HCD21, MCM4, YP9531.13, YPR019W
Pfam:
InterPro:
DNA replication licensing factor MCM4 in PDB entry 7qhs, assembly 1, front view.
DNA replication licensing factor MCM4 in PDB entry 7qhs, assembly 1, side view.
DNA replication licensing factor MCM4 in PDB entry 7qhs, assembly 1, top view.
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DNA replication licensing factor MCM6
Chain: 6
Length: 1017 amino acids
Theoretical weight: 113.11 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P53091 (Residues: 1-1017; Coverage: 100%)
Gene names: MCM6, YGL201C
Pfam:
InterPro:
DNA replication licensing factor MCM6 in PDB entry 7qhs, assembly 1, front view.
DNA replication licensing factor MCM6 in PDB entry 7qhs, assembly 1, side view.
DNA replication licensing factor MCM6 in PDB entry 7qhs, assembly 1, top view.
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DNA replication licensing factor MCM7
Chain: 7
Length: 845 amino acids
Theoretical weight: 95.05 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P38132 (Residues: 1-845; Coverage: 100%)
Gene names: CDC47, MCM7, YBR1441, YBR202W
Pfam:
InterPro:
DNA replication licensing factor MCM7 in PDB entry 7qhs, assembly 1, front view.
DNA replication licensing factor MCM7 in PDB entry 7qhs, assembly 1, side view.
DNA replication licensing factor MCM7 in PDB entry 7qhs, assembly 1, top view.
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DNA replication complex GINS protein PSF1
Chain: H
Length: 208 amino acids
Theoretical weight: 24.23 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
InterPro:
DNA replication complex GINS protein PSF1 in PDB entry 7qhs, assembly 1, front view.
DNA replication complex GINS protein PSF1 in PDB entry 7qhs, assembly 1, side view.
DNA replication complex GINS protein PSF1 in PDB entry 7qhs, assembly 1, top view.
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DNA replication complex GINS protein PSF2
Chain: I
Length: 213 amino acids
Theoretical weight: 25.1 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
InterPro:
DNA replication complex GINS protein PSF2 in PDB entry 7qhs, assembly 1, front view.
DNA replication complex GINS protein PSF2 in PDB entry 7qhs, assembly 1, side view.
DNA replication complex GINS protein PSF2 in PDB entry 7qhs, assembly 1, top view.
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DNA replication complex GINS protein PSF3
Chain: C
Length: 229 amino acids
Theoretical weight: 25.72 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: Q12146 (Residues: 1-194; Coverage: 100%)
Gene names: PSF3, YOL146W
Pfam:
InterPro:
DNA replication complex GINS protein PSF3 in PDB entry 7qhs, assembly 1, front view.
DNA replication complex GINS protein PSF3 in PDB entry 7qhs, assembly 1, side view.
DNA replication complex GINS protein PSF3 in PDB entry 7qhs, assembly 1, top view.
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DNA replication complex GINS protein SLD5
Chain: D
Length: 294 amino acids
Theoretical weight: 33.98 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: Q03406 (Residues: 1-294; Coverage: 100%)
Gene names: SLD5, YDR489W
Pfam:
InterPro:
DNA replication complex GINS protein SLD5 in PDB entry 7qhs, assembly 1, front view.
DNA replication complex GINS protein SLD5 in PDB entry 7qhs, assembly 1, side view.
DNA replication complex GINS protein SLD5 in PDB entry 7qhs, assembly 1, top view.
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Cell division control protein 45
Chain: E
Length: 657 amino acids
Theoretical weight: 75.15 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: Q08032 (Residues: 1-203, 204-650; Coverage: 100%)
Gene names: CDC45, L8004.11, SLD4, YLR103C
Pfam: CDC45-like protein
InterPro: CDC45 family
Cell division control protein 45 in PDB entry 7qhs, assembly 1, front view.
Cell division control protein 45 in PDB entry 7qhs, assembly 1, side view.
Cell division control protein 45 in PDB entry 7qhs, assembly 1, top view.
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DNA polymerase epsilon subunit B
Chain: F
Length: 689 amino acids
Theoretical weight: 78.43 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P24482 (Residues: 1-689; Coverage: 100%)
Gene names: DPB2, P9705.7, YPR175W
Pfam: DNA polymerase alpha/epsilon subunit B
InterPro:
DNA polymerase epsilon subunit B in PDB entry 7qhs, assembly 1, front view.
DNA polymerase epsilon subunit B in PDB entry 7qhs, assembly 1, side view.
DNA polymerase epsilon subunit B in PDB entry 7qhs, assembly 1, top view.
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DNA polymerase epsilon catalytic subunit A
Chain: G
Length: 2222 amino acids
Theoretical weight: 255.99 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P21951 (Residues: 1-2222; Coverage: 100%)
Gene names: DUN2, N0825, POL2, YNL262W
Pfam:
InterPro:
DNA polymerase epsilon catalytic subunit A in PDB entry 7qhs, assembly 1, front view.
DNA polymerase epsilon catalytic subunit A in PDB entry 7qhs, assembly 1, side view.
DNA polymerase epsilon catalytic subunit A in PDB entry 7qhs, assembly 1, top view.
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DNA replication licensing factor MCM5
Chain: 5
Length: 775 amino acids
Theoretical weight: 86.51 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Saccharomyces cerevisiae
InterPro:
DNA replication licensing factor MCM5 in PDB entry 7qhs, assembly 1, front view.
DNA replication licensing factor MCM5 in PDB entry 7qhs, assembly 1, side view.
DNA replication licensing factor MCM5 in PDB entry 7qhs, assembly 1, top view.
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DNA chain A
Name: DNA (26-MER)
Representative chains: A
Length: 26 nucleotides
Theoretical weight: 8.1 KDa
DNA (26-MER) in PDB entry 7qhs, assembly 1, front view.
DNA (26-MER) in PDB entry 7qhs, assembly 1, side view.
DNA (26-MER) in PDB entry 7qhs, assembly 1, top view.
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DNA chain B
Name: DNA (26-MER)
Representative chains: B
Length: 26 nucleotides
Theoretical weight: 7.86 KDa
DNA (26-MER) in PDB entry 7qhs, assembly 1, front view.
DNA (26-MER) in PDB entry 7qhs, assembly 1, side view.
DNA (26-MER) in PDB entry 7qhs, assembly 1, top view.
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