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In vitro assembled 266/297 - 391 tau filaments with KCl (10b)

Electron Microscopy
2.59Å resolution
PDB entry 7r5h coloured by chain, front view.
PDB entry 7r5h coloured by chain, side view.
PDB entry 7r5h coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo hexamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Microtubule-associated protein tau
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Multimeric state: homo hexamer
Accessible surface area: 26319.87 Å2
Buried surface area: 28988.99 Å2
Dissociation area: 1,450.26 Å2
Dissociation energy (ΔGdiss): -2.42 kcal/mol
Dissociation entropy (TΔSdiss): 13.5 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-145403

Macromolecules

Microtubule-associated protein tau
Chains: A, B, C, D, E, F
Length: 441 amino acids
Theoretical weight: 45.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10636 (Residues: 1-758; Coverage: 58%)
  • Best match: P10636-8 (Residues: 1-441)
Gene names: MAPT, MAPTL, MTBT1, TAU
Pfam: Tau and MAP protein, tubulin-binding repeat
InterPro:
Microtubule-associated protein tau in PDB entry 7r5h, assembly 1, front view.
Microtubule-associated protein tau in PDB entry 7r5h, assembly 1, side view.
Microtubule-associated protein tau in PDB entry 7r5h, assembly 1, top view.
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