› › Structure analysis

Cryo-EM structure of CH235.12 in complex with HIV-1 Env trimer CH505TF.N279K.G458Y.SOSIP.664 with high-mannose glycans

Electron Microscopy
4.19Å resolution
PDB entry 7tco coloured by chain, front view.
PDB entry 7tco coloured by chain, side view.
PDB entry 7tco coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dodecamer (preferred)
Entry contents: 4 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Envelope glycoprotein gp160 and IG-heavy chain and IG-light kappa chain
hide full assembly name
Multimeric state: hetero dodecamer
Accessible surface area: 134624.13 Å2
Buried surface area: 54105.0 Å2
Dissociation area: 6,081.87 Å2
Dissociation energy (ΔGdiss): 39.79 kcal/mol
Dissociation entropy (TΔSdiss): 42.87 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-224856

Macromolecules

Envelope glycoprotein gp160
Chains: A, E, M
Length: 461 amino acids
Theoretical weight: 52.02 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: M4M0W3 (Residues: 31-488; Coverage: 54%)
Gene name: env
Pfam: Envelope glycoprotein GP120
Envelope glycoprotein gp160 in PDB entry 7tco, assembly 1, front view.
Envelope glycoprotein gp160 in PDB entry 7tco, assembly 1, side view.
Envelope glycoprotein gp160 in PDB entry 7tco, assembly 1, top view.
Molecule details ›

Search similar proteins

Transmembrane protein gp41
Chains: B, F, N
Length: 160 amino acids
Theoretical weight: 18.15 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q2N0S5 (Residues: 508-661; Coverage: 18%)
Gene name: env
Pfam: Retroviral envelope protein
Transmembrane protein gp41 in PDB entry 7tco, assembly 1, front view.
Transmembrane protein gp41 in PDB entry 7tco, assembly 1, side view.
Transmembrane protein gp41 in PDB entry 7tco, assembly 1, top view.
Molecule details ›

Search similar proteins

CH235.12 Fab Heavy Chain
Chains: C, G, O
Length: 225 amino acids
Theoretical weight: 24.32 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
CH235.12 Fab Heavy Chain in PDB entry 7tco, assembly 1, front view.
CH235.12 Fab Heavy Chain in PDB entry 7tco, assembly 1, side view.
CH235.12 Fab Heavy Chain in PDB entry 7tco, assembly 1, top view.
Molecule details ›

Search similar proteins

CH235.12 Fab Light Chain
Chains: D, H, P
Length: 213 amino acids
Theoretical weight: 23.45 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
CH235.12 Fab Light Chain in PDB entry 7tco, assembly 1, front view.
CH235.12 Fab Light Chain in PDB entry 7tco, assembly 1, side view.
CH235.12 Fab Light Chain in PDB entry 7tco, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links