› 7tj8

Electron Microscopy
3.2Å resolution

Cryo-EM structure of the human Nax channel in complex with beta3 solved in nanodiscs

Released:
DOI: 10.2210/pdb7tj8/pdb
PDB entry 7tj8 coloured by chain, front view.
PDB entry 7tj8 coloured by chain, side view.
PDB entry 7tj8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure-guided unlocking of NaX reveals a non-selective tetrodotoxin-sensitive cation channel.
Noland CL, Chua HC, Kschonsak M, Heusser SA, Braun N, Chang T, Tam C, Tang J, Arthur CP, Ciferri C, Pless SA, Payandeh J
Nat Commun 13 1416 (2022)
PMID: 35301303
Related structures: EMD-25919

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169523 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Sodium channel protein type 7 subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 1737 amino acids
Theoretical weight: 199.68 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q01118 (Residues: 1-1682; Coverage: 100%)
Gene names: SCN6A, SCN7A
Sequence domains:
Sodium channel regulatory subunit beta-3 Chain: B
Molecule details ›
Chain: B
Length: 215 amino acids
Theoretical weight: 24.72 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NY72 (Residues: 1-215; Coverage: 100%)
Gene names: KIAA1158, SCN3B
Sequence domains: Immunoglobulin V-set domain

Ligands and Environments

5 bound ligands:
Ligand PEV 3 x PEV
Ligand POV 3 x POV
Ligand PLM 6 x PLM
Ligand NAG 5 x NAG
Ligand CLR 1 x CLR
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-25919
Expression system: Homo sapiens

Quick links

Citations

1 review citation

Voltage-gated sodium channels: from roles and mechanisms in the metastatic cell behavior to clinical potential as therapeutic targets.
Sanchez-Sandoval et al. (2023)
3 other articles