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Calcitonin Receptor in complex with Gs and salmon calcitonin peptide

Electron Microscopy
2.6Å resolution
PDB entry 7tyn coloured by chain, front view.
PDB entry 7tyn coloured by chain, side view.
PDB entry 7tyn coloured by chain, top view.
Source organisms:
Assembly composition:
hetero hexamer (preferred)
Entry contents: 6 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero hexamer
Accessible surface area: 50408.49 Å2
Buried surface area: 24024.65 Å2
Dissociation area: 2,682.86 Å2
Dissociation energy (ΔGdiss): -3.73 kcal/mol
Dissociation entropy (TΔSdiss): 27.08 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-207680

Macromolecules

Calcitonin peptide-like domain-containing protein
Chain: P
Length: 33 amino acids
Theoretical weight: 3.44 KDa
Source organism: Salmo salar
Expression system: Not provided
Calcitonin peptide-like domain-containing protein in PDB entry 7tyn, assembly 1, front view.
Calcitonin peptide-like domain-containing protein in PDB entry 7tyn, assembly 1, side view.
Calcitonin peptide-like domain-containing protein in PDB entry 7tyn, assembly 1, top view.
13351015202530
 
102030CSNLSTCVLGKLSQELHKLQTYPRTNTGSGTP*
UniProt
B5XGR7
Chains
Domains
Secondary structure
Flexibility predictions
Interaction interfaces
Sequence conservation
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Calcitonin receptor
Chain: R
Length: 501 amino acids
Theoretical weight: 58.47 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
Calcitonin receptor in PDB entry 7tyn, assembly 1, front view.
Calcitonin receptor in PDB entry 7tyn, assembly 1, side view.
Calcitonin receptor in PDB entry 7tyn, assembly 1, top view.
150150100150200250300350400450500
 
200400MKTIIALSYIFCLVFADYKDDDDLEVLFQGPAAFSNQTYPTIEPKPFLYVVGRKKMMDAQYKCYDRMQQLPAYQGEGPYCNRTWDGWLCWDDTPAGVLSYQFCPDYFPDFDPSEKVTKYCDEKGVWFKHPENNRTWSNYTMCNAFTPEKLKNAYVLYYLAIVGHSLSIFTLVISLGIFVFFRSLGCQRVTLHKNMFLTYILNSMIIIIHLVEVVPNGELVRRDPVSCKILHFFHQYMMACNYFWMLCEGIYLHTLIVVAVFTEKQRLRWYYLLGWGFPLVPTTIHAITRAVYFNDNCWLSVETHLLYIIHGPVMAALVVNFFFLLNIVRVLVTKMRETHEAESHMYLKAVKATMILVPLLGIQFVVFPWRPSNKMLGKIYDYVMHSLIHFQGFFVATIYCFCNNEVQTTVKRQWAQFKIQWNQRWGRRPSNRSARAAAAAAEAGDIPIYICHQELRNEPANNQGEESAEIIPLNIIEQESSAPAGLEVLFQGPHHHHHHHH
UniProt
P30988
Chains
Domains
Secondary structure
Ligand binding sites
Interaction interfaces
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Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Chain: A
Length: 394 amino acids
Theoretical weight: 45.68 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short in PDB entry 7tyn, assembly 1, front view.
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short in PDB entry 7tyn, assembly 1, side view.
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short in PDB entry 7tyn, assembly 1, top view.
139450100150200250300350
 
100200300MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGESGKNTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGAQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQAALKLFDSIWNNKWLRDTSVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL
UniProt
P63092
Chains
Domains
Secondary structure
Flexibility predictions
Interaction interfaces
Sequence conservation
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Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Chain: B
Length: 350 amino acids
Theoretical weight: 38.53 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 7tyn, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 7tyn, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 7tyn, assembly 1, top view.
135050100150200250300350
 
100200300MHHHHHHGSSGSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN
UniProt
P62873
Chains
Domains
Secondary structure
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Sequence conservation
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Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Chain: G
Length: 71 amino acids
Theoretical weight: 7.86 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 7tyn, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 7tyn, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 7tyn, assembly 1, top view.
171510152025303540455055606570
 
204060MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFREKKFFCAIL
UniProt
P59768
Chains
Domains
Secondary structure
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Nanobody 35
Chain: N
Length: 138 amino acids
Theoretical weight: 15.14 KDa
Source organism: Lama glama
Expression system: Escherichia coli
Nanobody 35 in PDB entry 7tyn, assembly 1, front view.
Nanobody 35 in PDB entry 7tyn, assembly 1, side view.
Nanobody 35 in PDB entry 7tyn, assembly 1, top view.
1138102030405060708090100110120130
 
50100QVQLQESGGGLVQPGGSLRLSCAASGFTFSNYKMNWVRQAPGKGLEWVSDISQSGASISYTGSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYCARCPAPFTRDCFDVTSTTYAYRGQGTQVTVSSHHHHHHEPEA
Chains
Chain F (auth N)
Domains
Secondary structure
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