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Structure of PKA phosphorylated human RyR2-R2474S in the open state in the presence of Calmodulin

Electron Microscopy
2.93Å resolution
PDB entry 7ua4 coloured by chain, front view.
PDB entry 7ua4 coloured by chain, side view.
PDB entry 7ua4 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dodecamer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Ryanodine 2 complex
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Multimeric state: hetero dodecamer
Accessible surface area: 800023.68 Å2
Buried surface area: 57196.63 Å2
Dissociation area: 6,007.02 Å2
Dissociation energy (ΔGdiss): 17.83 kcal/mol
Dissociation entropy (TΔSdiss): 49.99 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-143994

Macromolecules

Peptidyl-prolyl cis-trans isomerase FKBP1B
Chains: E, F, G, H
Length: 108 amino acids
Theoretical weight: 11.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P68106 (Residues: 1-108; Coverage: 100%)
Gene names: FKBP12.6, FKBP1B, FKBP1L, FKBP9, OTK4
Pfam: FKBP-type peptidyl-prolyl cis-trans isomerase
InterPro:
Peptidyl-prolyl cis-trans isomerase FKBP1B in PDB entry 7ua4, assembly 1, front view.
Peptidyl-prolyl cis-trans isomerase FKBP1B in PDB entry 7ua4, assembly 1, side view.
Peptidyl-prolyl cis-trans isomerase FKBP1B in PDB entry 7ua4, assembly 1, top view.
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Calmodulin-1
Chains: I, J, K, L
Length: 149 amino acids
Theoretical weight: 16.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P0DP23 (Residues: 1-149; Coverage: 100%)
Gene names: CALM, CALM1, CAM, CAM1
Pfam: EF-hand domain pair
InterPro:
Calmodulin-1 in PDB entry 7ua4, assembly 1, front view.
Calmodulin-1 in PDB entry 7ua4, assembly 1, side view.
Calmodulin-1 in PDB entry 7ua4, assembly 1, top view.
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Ryanodine receptor 2
Chains: A, B, C, D
Length: 4967 amino acids
Theoretical weight: 565.22 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q92736 (Residues: 1-4967; Coverage: 100%)
  • Best match: Q92736-2 (Residues: 1-4975)
Gene name: RYR2
Pfam:
InterPro:
Ryanodine receptor 2 in PDB entry 7ua4, assembly 1, front view.
Ryanodine receptor 2 in PDB entry 7ua4, assembly 1, side view.
Ryanodine receptor 2 in PDB entry 7ua4, assembly 1, top view.
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