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Structure of the DU422 SOSIP.664 trimer in complex with neutralizing antibody Fab fragments 10-1074 and BG24

Electron Microscopy
3.5Å resolution
PDB entry 7ucg coloured by chain, front view.
PDB entry 7ucg coloured by chain, side view.
PDB entry 7ucg coloured by chain, top view.
Source organisms:
Assembly composition:
hetero octadecamer (preferred)
Entry contents: 6 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Transmembrane protein gp41 and IG-heavy chain and IG-light lambda chain and IG-heavy chain and IG-light lambda chain
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Multimeric state: hetero octadecamer
Accessible surface area: 130650.62 Å2
Buried surface area: 79884.92 Å2
Dissociation area: 8,184.94 Å2
Dissociation energy (ΔGdiss): -56.84 kcal/mol
Dissociation entropy (TΔSdiss): 84.03 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-212088

Macromolecules

Transmembrane protein gp41
Chains: A, B, M
Length: 153 amino acids
Theoretical weight: 17.1 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q202J5 (Residues: 509-659; Coverage: 18%)
Gene name: env
Pfam: Retroviral envelope protein
InterPro: Retroviral envelope protein GP41-like
Transmembrane protein gp41 in PDB entry 7ucg, assembly 1, front view.
Transmembrane protein gp41 in PDB entry 7ucg, assembly 1, side view.
Transmembrane protein gp41 in PDB entry 7ucg, assembly 1, top view.
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BG24 CDRH2-v2 Fab heavy chain
Chains: C, D, N
Length: 234 amino acids
Theoretical weight: 25.5 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
BG24 CDRH2-v2 Fab heavy chain in PDB entry 7ucg, assembly 1, front view.
BG24 CDRH2-v2 Fab heavy chain in PDB entry 7ucg, assembly 1, side view.
BG24 CDRH2-v2 Fab heavy chain in PDB entry 7ucg, assembly 1, top view.
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BG24 light chain
Chains: E, F, O
Length: 205 amino acids
Theoretical weight: 21.93 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
BG24 light chain in PDB entry 7ucg, assembly 1, front view.
BG24 light chain in PDB entry 7ucg, assembly 1, side view.
BG24 light chain in PDB entry 7ucg, assembly 1, top view.
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Envelope glycoprotein gp160
Chains: G, I, P
Length: 507 amino acids
Theoretical weight: 57 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q202J5 (Residues: 28-503; Coverage: 56%)
Gene name: env
Pfam: Envelope glycoprotein GP120
InterPro:
Envelope glycoprotein gp160 in PDB entry 7ucg, assembly 1, front view.
Envelope glycoprotein gp160 in PDB entry 7ucg, assembly 1, side view.
Envelope glycoprotein gp160 in PDB entry 7ucg, assembly 1, top view.
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10-1074 Fab heavy chain
Chains: H, J, Q
Length: 243 amino acids
Theoretical weight: 26.39 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
10-1074 Fab heavy chain in PDB entry 7ucg, assembly 1, front view.
10-1074 Fab heavy chain in PDB entry 7ucg, assembly 1, side view.
10-1074 Fab heavy chain in PDB entry 7ucg, assembly 1, top view.
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10-1074 light chain
Chains: K, L, R
Length: 216 amino acids
Theoretical weight: 23.71 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
10-1074 light chain in PDB entry 7ucg, assembly 1, front view.
10-1074 light chain in PDB entry 7ucg, assembly 1, side view.
10-1074 light chain in PDB entry 7ucg, assembly 1, top view.
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