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Cryo-EM structure of PAPP-A in complex with IGFBP5

Electron Microscopy
3.28Å resolution
PDB entry 7ufg coloured by chain, front view.
PDB entry 7ufg coloured by chain, side view.
PDB entry 7ufg coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Pappalysin-1 and Insulin-like growth factor-binding protein 5
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Multimeric state: hetero tetramer
Accessible surface area: 103823.81 Å2
Buried surface area: 9791.63 Å2
Dissociation area: 2,377.77 Å2
Dissociation energy (ΔGdiss): 23.35 kcal/mol
Dissociation entropy (TΔSdiss): 17.07 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150255

Macromolecules

Pappalysin-1
Chains: A, B
Length: 1581 amino acids
Theoretical weight: 176.34 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q13219 (Residues: 81-1627; Coverage: 96%)
Gene name: PAPPA
Pfam:
InterPro:
Pappalysin-1 in PDB entry 7ufg, assembly 1, front view.
Pappalysin-1 in PDB entry 7ufg, assembly 1, side view.
Pappalysin-1 in PDB entry 7ufg, assembly 1, top view.
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Insulin-like growth factor-binding protein 5
Chains: C, D
Length: 272 amino acids
Theoretical weight: 30.88 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P24593 (Residues: 21-272; Coverage: 100%)
Gene names: IBP5, IGFBP5
Pfam:
InterPro:
Insulin-like growth factor-binding protein 5 in PDB entry 7ufg, assembly 1, front view.
Insulin-like growth factor-binding protein 5 in PDB entry 7ufg, assembly 1, side view.
Insulin-like growth factor-binding protein 5 in PDB entry 7ufg, assembly 1, top view.
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