Function and Biology Details
Reaction catalysed:
Cleavage of the 135-Met-|-Lys-136 bond in insulin-like growth factor binding protein (IGFBP)-4, and the 143-Ser-|-Lys-144 bond in IGFBP-5.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150255 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Pappalysin-1
Molecule details ›
Chains: A, B
Length: 1581 amino acids
Theoretical weight: 176.34 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 1581 amino acids
Theoretical weight: 176.34 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
Q13219 (Residues: 81-1627; Coverage: 96%)
Sequence domains:
Insulin-like growth factor-binding protein 5
Molecule details ›
Chains: C, D
Length: 272 amino acids
Theoretical weight: 30.88 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 272 amino acids
Theoretical weight: 30.88 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: P24593 (Residues: 21-272; Coverage: 100%)
Sequence domains:
