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Cryo-EM structure of BG24 Fabs with an inferred germline light chain and 10-1074 Fabs in complex with HIV-1 Env immunogen BG505-SOSIPv4.1-GT1 containing the N276 gp120 glycan- Class 1

Electron Microscopy
4.2Å resolution
PDB entry 7ugp coloured by chain, front view.
PDB entry 7ugp coloured by chain, side view.
PDB entry 7ugp coloured by chain, top view.
Source organisms:
Assembly composition:
hetero octadecamer (preferred)
Entry contents: 6 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Envelope glycoprotein gp160 and IG-heavy chain and IG-heavy chain and IG-light lambda chain and IG-light lambda chain
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Multimeric state: hetero octadecamer
Accessible surface area: 135354.23 Å2
Buried surface area: 67616.65 Å2
Dissociation area: 17,520.91 Å2
Dissociation energy (ΔGdiss): -32.58 kcal/mol
Dissociation entropy (TΔSdiss): 182.56 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-226239

Macromolecules

Envelope glycoprotein gp160
Chains: A, B, C
Length: 443 amino acids
Theoretical weight: 49.86 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q2N0S5 (Residues: 31-503; Coverage: 52%)
Gene name: env
Pfam: Envelope glycoprotein GP120
InterPro:
Envelope glycoprotein gp160 in PDB entry 7ugp, assembly 1, front view.
Envelope glycoprotein gp160 in PDB entry 7ugp, assembly 1, side view.
Envelope glycoprotein gp160 in PDB entry 7ugp, assembly 1, top view.
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Transmembrane protein gp41
Chains: D, E, F
Length: 128 amino acids
Theoretical weight: 14.58 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q2N0S5 (Residues: 516-661; Coverage: 15%)
Gene name: env
Pfam: Retroviral envelope protein
InterPro: Retroviral envelope protein GP41-like
Transmembrane protein gp41 in PDB entry 7ugp, assembly 1, front view.
Transmembrane protein gp41 in PDB entry 7ugp, assembly 1, side view.
Transmembrane protein gp41 in PDB entry 7ugp, assembly 1, top view.
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10-1074 Fab heavy chain
Chains: M, N, O
Length: 133 amino acids
Theoretical weight: 14.79 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
10-1074 Fab heavy chain in PDB entry 7ugp, assembly 1, front view.
10-1074 Fab heavy chain in PDB entry 7ugp, assembly 1, side view.
10-1074 Fab heavy chain in PDB entry 7ugp, assembly 1, top view.
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BG24 mature Fab heavy chain
Chains: G, H, I
Length: 120 amino acids
Theoretical weight: 13.38 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
BG24 mature Fab heavy chain in PDB entry 7ugp, assembly 1, front view.
BG24 mature Fab heavy chain in PDB entry 7ugp, assembly 1, side view.
BG24 mature Fab heavy chain in PDB entry 7ugp, assembly 1, top view.
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10-1074 Fab light chain
Chains: P, Q, R
Length: 107 amino acids
Theoretical weight: 11.7 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
10-1074 Fab light chain in PDB entry 7ugp, assembly 1, front view.
10-1074 Fab light chain in PDB entry 7ugp, assembly 1, side view.
10-1074 Fab light chain in PDB entry 7ugp, assembly 1, top view.
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BG24 mature Fab light chain
Chains: J, K, L
Length: 105 amino acids
Theoretical weight: 11.08 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
BG24 mature Fab light chain in PDB entry 7ugp, assembly 1, front view.
BG24 mature Fab light chain in PDB entry 7ugp, assembly 1, side view.
BG24 mature Fab light chain in PDB entry 7ugp, assembly 1, top view.
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