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Cryo-EM structure of Antibody 12-19 in complex with prefusion SARS-CoV-2 Spike glycoprotein

Electron Microscopy
3.03Å resolution
PDB entry 7ukm coloured by chain, front view.
PDB entry 7ukm coloured by chain, side view.
PDB entry 7ukm coloured by chain, top view.
Source organisms:
Assembly composition:
hetero nonamer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: SARS-CoV-2 post-fusion S2 Spike complex and antibody
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Multimeric state: hetero nonamer
Accessible surface area: 161415.13 Å2
Buried surface area: 48932.98 Å2
Dissociation area: 2,775.33 Å2
Dissociation energy (ΔGdiss): 11.21 kcal/mol
Dissociation entropy (TΔSdiss): 37.3 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-230847

Macromolecules

Spike glycoprotein
Chains: A, B, C
Length: 1273 amino acids
Theoretical weight: 141.21 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-1273; Coverage: 100%)
Gene names: 2, S
Pfam:
Spike glycoprotein in PDB entry 7ukm, assembly 1, front view.
Spike glycoprotein in PDB entry 7ukm, assembly 1, side view.
Spike glycoprotein in PDB entry 7ukm, assembly 1, top view.
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12-19 Fab Heavy Chain
Chains: H, M, X
Length: 133 amino acids
Theoretical weight: 14.96 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
12-19 Fab Heavy Chain in PDB entry 7ukm, assembly 1, front view.
12-19 Fab Heavy Chain in PDB entry 7ukm, assembly 1, side view.
12-19 Fab Heavy Chain in PDB entry 7ukm, assembly 1, top view.
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12-19 Fab Light Chain
Chains: L, N, Y
Length: 112 amino acids
Theoretical weight: 12.39 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
12-19 Fab Light Chain in PDB entry 7ukm, assembly 1, front view.
12-19 Fab Light Chain in PDB entry 7ukm, assembly 1, side view.
12-19 Fab Light Chain in PDB entry 7ukm, assembly 1, top view.
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