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CryoEM Structure of Inactive NTSR1 Bound to SR48692 and Nb6

Electron Microscopy
2.4Å resolution
PDB entry 7ul2 coloured by chain, front view.
PDB entry 7ul2 coloured by chain, side view.
PDB entry 7ul2 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Kappa-type opioid receptor, Neurotensin receptor type 1 and IG-heavy chain
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Multimeric state: hetero dimer
Accessible surface area: 18191.68 Å2
Buried surface area: 1297.07 Å2
Dissociation area: 578.28 Å2
Dissociation energy (ΔGdiss): -2.29 kcal/mol
Dissociation entropy (TΔSdiss): 10.26 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-225587

Macromolecules

Kappa-type opioid receptor; Neurotensin receptor type 1
Chain: R
Length: 419 amino acids
Theoretical weight: 47.08 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P30989 (Residues: 20-255, 307-418; Coverage: 83%)
  • Canonical: P41145 (Residues: 246-277; Coverage: 8%)
    • nullnull
Gene names: NTRR, NTSR1, OPRK, OPRK1
Pfam: 7 transmembrane receptor (rhodopsin family)
InterPro:
Kappa-type opioid receptor in PDB entry 7ul2, assembly 1, front view.
Kappa-type opioid receptor in PDB entry 7ul2, assembly 1, side view.
Kappa-type opioid receptor in PDB entry 7ul2, assembly 1, top view.
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Nanobody 6
Chain: D
Length: 133 amino acids
Theoretical weight: 14.73 KDa
Source organism: Lama glama
Expression system: Escherichia coli
InterPro:
Nanobody 6 in PDB entry 7ul2, assembly 1, front view.
Nanobody 6 in PDB entry 7ul2, assembly 1, side view.
Nanobody 6 in PDB entry 7ul2, assembly 1, top view.
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