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Human TMEM175 in an open state

Electron Microscopy
2.45Å resolution
PDB entry 7unl coloured by chain, front view.
PDB entry 7unl coloured by chain, side view.
PDB entry 7unl coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Endosomal/lysosomal proton channel TMEM175
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Multimeric state: homo dimer
Accessible surface area: 32257.93 Å2
Buried surface area: 8492.82 Å2
Dissociation area: 347.55 Å2
Dissociation energy (ΔGdiss): 1 kcal/mol
Dissociation entropy (TΔSdiss): 1.53 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-189703

Macromolecules

Endosomal/lysosomal proton channel TMEM175
Chains: A, B
Length: 504 amino acids
Theoretical weight: 55.67 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9BSA9 (Residues: 1-504; Coverage: 100%)
Gene name: TMEM175
Pfam: Endosomal/lysosomal potassium channel TMEM175
InterPro: Endosomal/lysosomal proton channel TMEM175-like
Endosomal/lysosomal proton channel TMEM175 in PDB entry 7unl, assembly 1, front view.
Endosomal/lysosomal proton channel TMEM175 in PDB entry 7unl, assembly 1, side view.
Endosomal/lysosomal proton channel TMEM175 in PDB entry 7unl, assembly 1, top view.
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