7v2w

Electron Microscopy
3.2Å resolution

protomer structure from the dimer of yeast THO complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126884 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
THO complex subunit HPR1 Chain: F
Molecule details ›
Chain: F
Length: 752 amino acids
Theoretical weight: 87.94 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P17629 (Residues: 1-752; Coverage: 100%)
Gene names: HPR1, YD9302.14, YDR138W
Sequence domains: THO complex subunit 1 transcription elongation factor
THO complex subunit 2 Chain: G
Molecule details ›
Chain: G
Length: 1597 amino acids
Theoretical weight: 184.16 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P53552 (Residues: 1-1597; Coverage: 100%)
Gene names: LDB5, N1209, N1835, RLR1, THO2, YNL139C, ZRG13
Sequence domains:
Protein TEX1 Chain: H
Molecule details ›
Chain: H
Length: 422 amino acids
Theoretical weight: 47.23 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P53851 (Residues: 1-422; Coverage: 100%)
Gene names: N0860, TEX1, YNL253W
Sequence domains: WD domain, G-beta repeat
THO complex subunit MFT1 Chain: I
Molecule details ›
Chain: I
Length: 392 amino acids
Theoretical weight: 45.06 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P33441 (Residues: 1-392; Coverage: 100%)
Gene names: MFT1, YML062C
Sequence domains: Tho complex subunit 7
THO complex subunit THP2 Chain: J
Molecule details ›
Chain: J
Length: 261 amino acids
Theoretical weight: 30.34 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O13539 (Residues: 1-261; Coverage: 100%)
Gene names: THP2, YHR167W
Sequence domains: Tho complex subunit THP2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-31669
Expression system: Spodoptera frugiperda