Function and Biology

protomer structure from the dimer of yeast THO complex

Source organism: Saccharomyces cerevisiae S288C
Biochemical function: protein binding
Biological process: mRNA export from nucleus
Cellular component: nucleus

Sequence families

Pfam Protein families (Pfam)
PF11262
Domain description: Transcription factor/nuclear export subunit protein 2
Occurring in:
  1. THO complex subunit 2
The deposited structure of PDB entry 7v2w contains 2 copies of Pfam domain PF11262 (Transcription factor/nuclear export subunit protein 2) in THO complex subunit 2. Showing 2 copies in chain B [auth G].

PF09432
Domain description: Tho complex subunit THP2
Occurring in:
  1. THO complex subunit THP2
The deposited structure of PDB entry 7v2w contains 1 copy of Pfam domain PF09432 (Tho complex subunit THP2) in THO complex subunit THP2. Showing 1 copy in chain E [auth J].

PF05615
Domain description: Tho complex subunit 7
Occurring in:
  1. THO complex subunit MFT1
The deposited structure of PDB entry 7v2w contains 1 copy of Pfam domain PF05615 (Tho complex subunit 7) in THO complex subunit MFT1. Showing 1 copy in chain D [auth I].

PF00400
Domain description: WD domain, G-beta repeat
Occurring in:
  1. Protein TEX1
The deposited structure of PDB entry 7v2w contains 1 copy of Pfam domain PF00400 (WD domain, G-beta repeat) in Protein TEX1. Showing 1 copy in chain C [auth H].

PF11732
Domain description: Transcription- and export-related complex subunit
Occurring in:
  1. THO complex subunit 2
The deposited structure of PDB entry 7v2w contains 1 copy of Pfam domain PF11732 (Transcription- and export-related complex subunit) in THO complex subunit 2. Showing 1 copy in chain B [auth G].

PF16134
Domain description: THO complex subunit 2 N-terminus
Occurring in:
  1. THO complex subunit 2
The deposited structure of PDB entry 7v2w contains 1 copy of Pfam domain PF16134 (THO complex subunit 2 N-terminus) in THO complex subunit 2. Showing 1 copy in chain B [auth G].

PF11957
Domain description: THO complex subunit 1 transcription elongation factor
Occurring in:
  1. THO complex subunit HPR1
The deposited structure of PDB entry 7v2w contains 1 copy of Pfam domain PF11957 (THO complex subunit 1 transcription elongation factor) in THO complex subunit HPR1. Showing 1 copy in chain A [auth F].

InterPro InterPro annotations
IPR001680
Domain description: WD40 repeat
Occurring in:
  1. Protein TEX1
IPR015943
Domain description: WD40/YVTN repeat-like-containing domain superfamily
Occurring in:
  1. Protein TEX1
IPR021418
Domain description: THO complex, subunitTHOC2, C-terminal
Occurring in:
  1. THO complex subunit 2
IPR018557
Domain description: THO complex subunit Thp2
Occurring in:
  1. THO complex subunit THP2
IPR008501
Domain description: THO complex subunit 7/Mft1
Occurring in:
  1. THO complex subunit MFT1
IPR036322
Domain description: WD40-repeat-containing domain superfamily
Occurring in:
  1. Protein TEX1
IPR040132
Domain description: TREX component Tex1/THOC3
Occurring in:
  1. Protein TEX1
IPR021726
Domain description: THO complex, subunitTHOC2, N-terminal
Occurring in:
  1. THO complex subunit 2
IPR040007
Domain description: THO complex subunit 2
Occurring in:
  1. THO complex subunit 2
IPR032302
Domain description: THO complex subunit 2, N-terminal domain
Occurring in:
  1. THO complex subunit 2
IPR021861
Domain description: THO complex, subunit THOC1
Occurring in:
  1. THO complex subunit HPR1