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protomer structure from the dimer of yeast THO complex

Electron Microscopy
3.2Å resolution
PDB entry 7v2w coloured by chain, front view.
PDB entry 7v2w coloured by chain, side view.
PDB entry 7v2w coloured by chain, top view.
Source organism: Saccharomyces cerevisiae S288C
Assembly composition:
hetero pentamer (preferred)
Entry contents: 5 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: THO complex
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Multimeric state: hetero pentamer
Accessible surface area: 126900.76 Å2
Buried surface area: 44555.06 Å2
Dissociation area: 2,613.36 Å2
Dissociation energy (ΔGdiss): 19.11 kcal/mol
Dissociation entropy (TΔSdiss): 15.49 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-126884

Macromolecules

THO complex subunit HPR1
Chain: F
Length: 752 amino acids
Theoretical weight: 87.94 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P17629 (Residues: 1-752; Coverage: 100%)
Gene names: HPR1, YD9302.14, YDR138W
Pfam: THO complex subunit 1 transcription elongation factor
InterPro: THO complex, subunit THOC1
THO complex subunit HPR1 in PDB entry 7v2w, assembly 1, front view.
THO complex subunit HPR1 in PDB entry 7v2w, assembly 1, side view.
THO complex subunit HPR1 in PDB entry 7v2w, assembly 1, top view.
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THO complex subunit 2
Chain: G
Length: 1597 amino acids
Theoretical weight: 184.16 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P53552 (Residues: 1-1597; Coverage: 100%)
Gene names: LDB5, N1209, N1835, RLR1, THO2, YNL139C, ZRG13
Pfam:
InterPro:
THO complex subunit 2 in PDB entry 7v2w, assembly 1, front view.
THO complex subunit 2 in PDB entry 7v2w, assembly 1, side view.
THO complex subunit 2 in PDB entry 7v2w, assembly 1, top view.
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Protein TEX1
Chain: H
Length: 422 amino acids
Theoretical weight: 47.23 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P53851 (Residues: 1-422; Coverage: 100%)
Gene names: N0860, TEX1, YNL253W
Pfam: WD domain, G-beta repeat
InterPro:
Protein TEX1 in PDB entry 7v2w, assembly 1, front view.
Protein TEX1 in PDB entry 7v2w, assembly 1, side view.
Protein TEX1 in PDB entry 7v2w, assembly 1, top view.
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THO complex subunit MFT1
Chain: I
Length: 392 amino acids
Theoretical weight: 45.06 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P33441 (Residues: 1-392; Coverage: 100%)
Gene names: MFT1, YML062C
Pfam: Tho complex subunit 7
InterPro: THO complex subunit 7/Mft1
THO complex subunit MFT1 in PDB entry 7v2w, assembly 1, front view.
THO complex subunit MFT1 in PDB entry 7v2w, assembly 1, side view.
THO complex subunit MFT1 in PDB entry 7v2w, assembly 1, top view.
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THO complex subunit THP2
Chain: J
Length: 261 amino acids
Theoretical weight: 30.34 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O13539 (Residues: 1-261; Coverage: 100%)
Gene names: THP2, YHR167W
Pfam: Tho complex subunit THP2
InterPro: THO complex subunit Thp2
THO complex subunit THP2 in PDB entry 7v2w, assembly 1, front view.
THO complex subunit THP2 in PDB entry 7v2w, assembly 1, side view.
THO complex subunit THP2 in PDB entry 7v2w, assembly 1, top view.
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