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Crystal structure of PDE8A catalytic domain in complex with 10

X-ray diffraction
2.5Å resolution
PDB entry 7vsl coloured by chain, front view.
PDB entry 7vsl coloured by chain, side view.
PDB entry 7vsl coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
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Multimeric state: monomeric
Accessible surface area: 15499.6 Å2
Buried surface area: 242.52 Å2
Dissociation area: 73.6 Å2
Dissociation energy (ΔGdiss): 15.65 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-130049

Macromolecules

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
Chain: A
Length: 338 amino acids
Theoretical weight: 39.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O60658 (Residues: 482-819; Coverage: 41%)
Gene name: PDE8A
Pfam: 3'5'-cyclic nucleotide phosphodiesterase
InterPro:
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A in PDB entry 7vsl, assembly 1, front view.
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A in PDB entry 7vsl, assembly 1, side view.
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A in PDB entry 7vsl, assembly 1, top view.
PDBe-KB: UniProt Coverage View: O60658  
133850100150200250300
 
100200300
UniProt
O60658
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Ligand binding sites
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