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cryo-EM structure of human NaV1.3/beta1/beta2-bulleyaconitineA

Electron Microscopy
3.3Å resolution
PDB entry 7w77 coloured by chain, front view.
PDB entry 7w77 coloured by chain, side view.
PDB entry 7w77 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Nav1.3 voltage-gated sodium channel complex, SCN1B-SCN2B variant
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Multimeric state: hetero trimer
Accessible surface area: 71644.64 Å2
Buried surface area: 7312.4 Å2
Dissociation area: 375.03 Å2
Dissociation energy (ΔGdiss): -7.07 kcal/mol
Dissociation entropy (TΔSdiss): 12.54 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-130220

Macromolecules

Sodium channel regulatory subunit beta-1
Chain: B
Length: 218 amino acids
Theoretical weight: 24.73 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q07699 (Residues: 1-218; Coverage: 100%)
Gene name: SCN1B
Pfam: Immunoglobulin V-set domain
InterPro:
Sodium channel subunit beta-1 in PDB entry 7w77, assembly 1, front view.
Sodium channel subunit beta-1 in PDB entry 7w77, assembly 1, side view.
Sodium channel subunit beta-1 in PDB entry 7w77, assembly 1, top view.
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Sodium channel regulatory subunit beta-2
Chain: C
Length: 215 amino acids
Theoretical weight: 24.36 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O60939 (Residues: 1-215; Coverage: 100%)
Gene names: SCN2B, UNQ326/PRO386
Pfam: Immunoglobulin V-set domain
InterPro:
Sodium channel subunit beta-2 in PDB entry 7w77, assembly 1, front view.
Sodium channel subunit beta-2 in PDB entry 7w77, assembly 1, side view.
Sodium channel subunit beta-2 in PDB entry 7w77, assembly 1, top view.
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Sodium channel protein type 3 subunit alpha
Chain: D
Length: 1951 amino acids
Theoretical weight: 221.04 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NY46 (Residues: 1-1951; Coverage: 98%)
Gene names: KIAA1356, NAC3, SCN3A
Pfam:
InterPro:
Sodium channel protein type 3 subunit alpha in PDB entry 7w77, assembly 1, front view.
Sodium channel protein type 3 subunit alpha in PDB entry 7w77, assembly 1, side view.
Sodium channel protein type 3 subunit alpha in PDB entry 7w77, assembly 1, top view.
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