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Cryo-EM Structure of Leishmanial GDP-mannose pyrophosphorylase in complex with GDP-Mannose

Electron Microscopy
3.5Å resolution
PDB entry 7wht coloured by chain, front view.
PDB entry 7wht coloured by chain, side view.
PDB entry 7wht coloured by chain, top view.
Source organism: Leishmania donovani
Assembly composition:
homo hexamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: mannose-1-phosphate guanylyltransferase
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Multimeric state: homo hexamer
Accessible surface area: 85775.9 Å2
Buried surface area: 14588.24 Å2
Dissociation area: 3,981.83 Å2
Dissociation energy (ΔGdiss): -6.78 kcal/mol
Dissociation entropy (TΔSdiss): 72.59 kcal/mol
Symmetry number: 6
PDBe Complex ID: PDB-CPX-123161

Macromolecules

mannose-1-phosphate guanylyltransferase
Chains: A, B, C, D, E, F
Length: 379 amino acids
Theoretical weight: 41.78 KDa
Source organism: Leishmania donovani
Expression system: Escherichia coli
UniProt:
  • Canonical: E9BG32 (Residues: 1-379; Coverage: 100%)
Gene names: CGC21_17635, LDBPK_230120
Pfam:
InterPro:
mannose-1-phosphate guanylyltransferase in PDB entry 7wht, assembly 1, front view.
mannose-1-phosphate guanylyltransferase in PDB entry 7wht, assembly 1, side view.
mannose-1-phosphate guanylyltransferase in PDB entry 7wht, assembly 1, top view.
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