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Cryo-EM structure of the human TRPC5 ion channel in complex with G alpha i3 subunits, class1

Electron Microscopy
3.93Å resolution
PDB entry 7x6i coloured by chain, front view.
PDB entry 7x6i coloured by chain, side view.
PDB entry 7x6i coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero octamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Short transient receptor potential channel complex, TRPC5 variant and Guanine nucleotide-binding protein G(i) subunit alpha-3
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Multimeric state: hetero octamer
Accessible surface area: 182028.17 Å2
Buried surface area: 57138.98 Å2
Dissociation area: 2,715.28 Å2
Dissociation energy (ΔGdiss): -27.45 kcal/mol
Dissociation entropy (TΔSdiss): 58.39 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-216274

Macromolecules

Short transient receptor potential channel 5
Chains: A, B, C, D
Length: 773 amino acids
Theoretical weight: 89.95 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UL62 (Residues: 1-765; Coverage: 79%)
Gene names: TRP5, TRPC5
Pfam:
InterPro:
Short transient receptor potential channel 5 in PDB entry 7x6i, assembly 1, front view.
Short transient receptor potential channel 5 in PDB entry 7x6i, assembly 1, side view.
Short transient receptor potential channel 5 in PDB entry 7x6i, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q9UL62  
1773100200300400500600700
 
200400600MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYNVNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRRPSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRRNLRSFTERNADSLIQNQHYQEVIRNLVKRYVAAMIRNSKTHEGLTEENFKELKQDISSFRYEVLDLLGNRKSRLEVLFQ
UniProt
Q9UL62
Chains
Domains
Secondary structure
Ligand binding sites
Interaction interfaces
Sequence conservation
Molecule details ›

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Guanine nucleotide-binding protein G(i) subunit alpha-3
Chains: E, F, G, H
Length: 360 amino acids
Theoretical weight: 41.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: P08754 (Residues: 1-119, 120-354; Coverage: 100%)
Gene name: GNAI3
Pfam: G-protein alpha subunit
InterPro:
Guanine nucleotide-binding protein G(i) subunit alpha-3 in PDB entry 7x6i, assembly 1, front view.
Guanine nucleotide-binding protein G(i) subunit alpha-3 in PDB entry 7x6i, assembly 1, side view.
Guanine nucleotide-binding protein G(i) subunit alpha-3 in PDB entry 7x6i, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P08754  
136050100150200250300350
 
100200300MGCTLSAEDKAAVERSKMIDRNLREDGEKAAKEVKLLLLGAGESGKSTIVKQMKIIHEDGYSEDECKQYKVVVYSNTIQSIIAIIRAMGRLKIDFGEAARADDARQLFVLAGSAEEGVMHHHHHHTPELAGVIKRLWRDGGVQACFSRSREYQLNDSASYYLNDLDRISQSNYIPTQQDVLRTRVKTTGIVETHFTFKDLYFKMFDVGGLRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTETSIILFLNKKDLFEEKIKRSPLTICYPEYTGSNTYEEAAAYIQCQFEDLNRRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKECGLY
UniProt
P08754
Chains
Domains
Secondary structure
Ligand binding sites
Interaction interfaces
Sequence conservation
Molecule details ›

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