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Cryo-EM structure of SARS-CoV-2 Delta RBD in complex with BA7054 and BA7125 fab (local refinement)

Electron Microscopy
3.2Å resolution
PDB entry 7xcz coloured by chain, front view.
PDB entry 7xcz coloured by chain, side view.
PDB entry 7xcz coloured by chain, top view.
Source organisms:
Assembly composition:
hetero pentamer (preferred)
Entry contents: 5 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Spike protein S2' and IG-heavy chain and IG-light kappa chain and IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero pentamer
Accessible surface area: 47043.82 Å2
Buried surface area: 10869.64 Å2
Dissociation area: 740.37 Å2
Dissociation energy (ΔGdiss): -7.4 kcal/mol
Dissociation entropy (TΔSdiss): 14.36 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-225258

Macromolecules

Spike protein S1
Chain: A
Length: 196 amino acids
Theoretical weight: 22.07 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
Spike protein S1 in PDB entry 7xcz, assembly 1, front view.
Spike protein S1 in PDB entry 7xcz, assembly 1, side view.
Spike protein S1 in PDB entry 7xcz, assembly 1, top view.
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BA7054 fab
Chain: D
Length: 224 amino acids
Theoretical weight: 23.71 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
BA7054 fab in PDB entry 7xcz, assembly 1, front view.
BA7054 fab in PDB entry 7xcz, assembly 1, side view.
BA7054 fab in PDB entry 7xcz, assembly 1, top view.
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BA7054 fab
Chain: E
Length: 214 amino acids
Theoretical weight: 23.19 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
BA7054 fab in PDB entry 7xcz, assembly 1, front view.
BA7054 fab in PDB entry 7xcz, assembly 1, side view.
BA7054 fab in PDB entry 7xcz, assembly 1, top view.
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BA7125 fab
Chain: B
Length: 220 amino acids
Theoretical weight: 23.51 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
BA7125 fab in PDB entry 7xcz, assembly 1, front view.
BA7125 fab in PDB entry 7xcz, assembly 1, side view.
BA7125 fab in PDB entry 7xcz, assembly 1, top view.
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BA7125 fab
Chain: C
Length: 215 amino acids
Theoretical weight: 23.33 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
BA7125 fab in PDB entry 7xcz, assembly 1, front view.
BA7125 fab in PDB entry 7xcz, assembly 1, side view.
BA7125 fab in PDB entry 7xcz, assembly 1, top view.
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