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Cryo-EM structure of a class T GPCR in ligand-free state

Electron Microscopy
3.08Å resolution
PDB entry 7xp5 coloured by chain, front view.
PDB entry 7xp5 coloured by chain, side view.
PDB entry 7xp5 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero pentamer (preferred)
Entry contents: 5 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentamer
Accessible surface area: 47906.57 Å2
Buried surface area: 11620.29 Å2
Dissociation area: 1,103.29 Å2
Dissociation energy (ΔGdiss): 1.09 kcal/mol
Dissociation entropy (TΔSdiss): 12.52 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-225499

Macromolecules

Endoglucanase H; Taste receptor type 2 member 46
Chain: R
Length: 802 amino acids
Theoretical weight: 91.12 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P16218 (Residues: 26-304; Coverage: 30%)
  • Canonical: P59540 (Residues: 2-309; Coverage: 100%)
    • nullnull
Gene names: Cthe_1472, TAS2R46, celH
Pfam:
InterPro:
Endoglucanase H in PDB entry 7xp5, assembly 1, front view.
Endoglucanase H in PDB entry 7xp5, assembly 1, side view.
Endoglucanase H in PDB entry 7xp5, assembly 1, top view.
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Guanine nucleotide-binding protein G(s) subunit alpha isoforms short; Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Chain: A
Length: 264 amino acids
Theoretical weight: 30.58 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P63092 (Residues: 5-389; Coverage: 62%)
  • Best match: P63092-2 (Residues: 5-375)
Gene names: GNAS, GNAS1, GSP
Pfam: G-protein alpha subunit
InterPro:
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short in PDB entry 7xp5, assembly 1, front view.
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short in PDB entry 7xp5, assembly 1, side view.
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short in PDB entry 7xp5, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Chain: B
Length: 366 amino acids
Theoretical weight: 39.73 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P62873 (Residues: 1-340; Coverage: 100%)
Gene name: GNB1
Pfam: WD domain, G-beta repeat
InterPro:
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 7xp5, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 7xp5, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 7xp5, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Chain: G
Length: 71 amino acids
Theoretical weight: 7.86 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P59768 (Residues: 1-71; Coverage: 100%)
Gene name: GNG2
Pfam: GGL domain
InterPro:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 7xp5, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 7xp5, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 7xp5, assembly 1, top view.
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Nanobody 35
Chain: N
Length: 139 amino acids
Theoretical weight: 15.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
InterPro:
Nanobody 35 in PDB entry 7xp5, assembly 1, front view.
Nanobody 35 in PDB entry 7xp5, assembly 1, side view.
Nanobody 35 in PDB entry 7xp5, assembly 1, top view.
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