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Cryo-EM structure of the octreotide-bound SSTR2-miniGo-scFv16 complex

Electron Microscopy
3.25Å resolution
PDB entry 7y24 coloured by chain, front view.
PDB entry 7y24 coloured by chain, side view.
PDB entry 7y24 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero hexamer (preferred)
Entry contents: 6 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero hexamer
Accessible surface area: 45917.29 Å2
Buried surface area: 10818.25 Å2
Dissociation area: 2,065.07 Å2
Dissociation energy (ΔGdiss): -9.33 kcal/mol
Dissociation entropy (TΔSdiss): 27.44 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-225116

Macromolecules

Guanine nucleotide-binding protein G(o) subunit alpha
Chain: A
Length: 224 amino acids
Theoretical weight: 25.06 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P09471 (Residues: 5-57, 182-354; Coverage: 61%)
Gene name: GNAO1
Pfam: G-protein alpha subunit
InterPro:
Guanine nucleotide-binding protein G(o) subunit alpha in PDB entry 7y24, assembly 1, front view.
Guanine nucleotide-binding protein G(o) subunit alpha in PDB entry 7y24, assembly 1, side view.
Guanine nucleotide-binding protein G(o) subunit alpha in PDB entry 7y24, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Chain: B
Length: 338 amino acids
Theoretical weight: 37.2 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P62873 (Residues: 3-340; Coverage: 99%)
Gene name: GNB1
Pfam: WD domain, G-beta repeat
InterPro:
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 7y24, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 7y24, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 7y24, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Chain: G
Length: 56 amino acids
Theoretical weight: 6.16 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P59768 (Residues: 7-62; Coverage: 79%)
Gene name: GNG2
Pfam: GGL domain
InterPro:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 7y24, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 7y24, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 7y24, assembly 1, top view.
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single Fab chain (svFv16)
Chain: S
Length: 246 amino acids
Theoretical weight: 26.22 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
single Fab chain (svFv16) in PDB entry 7y24, assembly 1, front view.
single Fab chain (svFv16) in PDB entry 7y24, assembly 1, side view.
single Fab chain (svFv16) in PDB entry 7y24, assembly 1, top view.
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Octreotide
Chain: C
Length: 8 amino acids
Theoretical weight: 1.04 KDa
Source organism: Homo sapiens
Expression system: Not provided
Octreotide in PDB entry 7y24, assembly 1, front view.
Octreotide in PDB entry 7y24, assembly 1, side view.
Octreotide in PDB entry 7y24, assembly 1, top view.
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Somatostatin receptor type 2
Chain: E
Length: 327 amino acids
Theoretical weight: 36.74 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P30874 (Residues: 1-327; Coverage: 89%)
Gene name: SSTR2
Pfam: 7 transmembrane receptor (rhodopsin family)
InterPro:
Somatostatin receptor type 2 in PDB entry 7y24, assembly 1, front view.
Somatostatin receptor type 2 in PDB entry 7y24, assembly 1, side view.
Somatostatin receptor type 2 in PDB entry 7y24, assembly 1, top view.
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