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SARS-CoV-2 spike glycoprotein trimer complexed with Fab fragment of anti-RBD antibody E7

Electron Microscopy
3.12Å resolution
PDB entry 7y71 coloured by chain, front view.
PDB entry 7y71 coloured by chain, side view.
PDB entry 7y71 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero pentamer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: SARS-CoV-2 post-fusion S2 Spike complex and antibody
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Multimeric state: hetero pentamer
Accessible surface area: 168299.79 Å2
Buried surface area: 35771.23 Å2
Dissociation area: 1,219.59 Å2
Dissociation energy (ΔGdiss): -0.78 kcal/mol
Dissociation entropy (TΔSdiss): 15.35 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-272980

Macromolecules

Fab E7 light chain
Chain: P
Length: 219 amino acids
Theoretical weight: 23.92 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Fab E7 light chain in PDB entry 7y71, assembly 1, front view.
Fab E7 light chain in PDB entry 7y71, assembly 1, side view.
Fab E7 light chain in PDB entry 7y71, assembly 1, top view.
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Fab E7 heavy chain
Chain: O
Length: 221 amino acids
Theoretical weight: 23.34 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Fab E7 heavy chain in PDB entry 7y71, assembly 1, front view.
Fab E7 heavy chain in PDB entry 7y71, assembly 1, side view.
Fab E7 heavy chain in PDB entry 7y71, assembly 1, top view.
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Spike glycoprotein
Chains: A, B, C
Length: 1198 amino acids
Theoretical weight: 132.86 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 16-1213; Coverage: 95%)
Gene names: 2, S
Pfam:
Spike glycoprotein in PDB entry 7y71, assembly 1, front view.
Spike glycoprotein in PDB entry 7y71, assembly 1, side view.
Spike glycoprotein in PDB entry 7y71, assembly 1, top view.
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