Function and Biology

Cryo-EM structure of human GABA transporter GAT1 bound with tiagabine in NaCl solution in an inward-open state at 3.2 angstrom

Source organism: Homo sapiens
Biochemical function: metal ion binding
Biological process: response to methamphetamine hydrochloride
Cellular component: GABA-ergic synapse

Sequence family

Pfam Protein family (Pfam)
PF00209
Domain description: Sodium:neurotransmitter symporter family
Occurring in:
  1. Sodium- and chloride-dependent GABA transporter 1
The deposited structure of PDB entry 7y7z contains 1 copy of Pfam domain PF00209 (Sodium:neurotransmitter symporter family) in Sodium- and chloride-dependent GABA transporter 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000175
Domain description: Sodium:neurotransmitter symporter
Occurring in:
  1. Sodium- and chloride-dependent GABA transporter 1
IPR002980
Domain description: Sodium:neurotransmitter symporter, GABA, GAT-1
Occurring in:
  1. Sodium- and chloride-dependent GABA transporter 1
IPR037272
Domain description: Sodium:neurotransmitter symporter superfamily
Occurring in:
  1. Sodium- and chloride-dependent GABA transporter 1