› › Structure analysis

Cryo-EM structure of human GABA transporter GAT1 bound with tiagabine in NaCl solution in an inward-open state at 3.2 angstrom

Electron Microscopy
3.2Å resolution
PDB entry 7y7z coloured by chain, front view.
PDB entry 7y7z coloured by chain, side view.
PDB entry 7y7z coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Sodium- and chloride-dependent GABA transporter 1
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 22455.7 Å2
Buried surface area: 659.93 Å2
Dissociation area: 63 Å2
Dissociation energy (ΔGdiss): 13.29 kcal/mol
Dissociation entropy (TΔSdiss): -0.83 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-151757

Macromolecules

Sodium- and chloride-dependent GABA transporter 1
Chain: A
Length: 632 amino acids
Theoretical weight: 70.9 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P30531 (Residues: 1-599; Coverage: 100%)
Gene names: GABATR, GABT1, GAT1, SLC6A1
Pfam: Sodium:neurotransmitter symporter family
InterPro:
Sodium- and chloride-dependent GABA transporter 1 in PDB entry 7y7z, assembly 1, front view.
Sodium- and chloride-dependent GABA transporter 1 in PDB entry 7y7z, assembly 1, side view.
Sodium- and chloride-dependent GABA transporter 1 in PDB entry 7y7z, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links