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Cryo-EM Structure of FGF23-FGFR3c-aKlotho-HS Quaternary Complex

Electron Microscopy
3.2Å resolution
PDB entry 7ysu coloured by chain, front view.
PDB entry 7ysu coloured by chain, side view.
PDB entry 7ysu coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 62413.45 Å2
Buried surface area: 17116.13 Å2
Dissociation area: 2,182.49 Å2
Dissociation energy (ΔGdiss): 4.66 kcal/mol
Dissociation entropy (TΔSdiss): 14.36 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-210862

Macromolecules

Klotho
Chain: A
Length: 942 amino acids
Theoretical weight: 108.4 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UEF7 (Residues: 34-975; Coverage: 96%)
Gene name: KL
Pfam: Glycosyl hydrolase family 1
InterPro:
Klotho in PDB entry 7ysu, assembly 1, front view.
Klotho in PDB entry 7ysu, assembly 1, side view.
Klotho in PDB entry 7ysu, assembly 1, top view.
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Fibroblast growth factor receptor 3
Chains: C, E
Length: 211 amino acids
Theoretical weight: 23.36 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P22607 (Residues: 148-358; Coverage: 27%)
Gene names: FGFR3, JTK4
Pfam:
InterPro:
Fibroblast growth factor receptor 3 in PDB entry 7ysu, assembly 1, front view.
Fibroblast growth factor receptor 3 in PDB entry 7ysu, assembly 1, side view.
Fibroblast growth factor receptor 3 in PDB entry 7ysu, assembly 1, top view.
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Fibroblast growth factor 23 N-terminal peptide
Chain: B
Length: 179 amino acids
Theoretical weight: 20.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9GZV9 (Residues: 25-203; Coverage: 79%)
Gene names: FGF23, HYPF, UNQ3027/PRO9828
Pfam: Fibroblast growth factor
InterPro:
Fibroblast growth factor 23 N-terminal peptide in PDB entry 7ysu, assembly 1, front view.
Fibroblast growth factor 23 N-terminal peptide in PDB entry 7ysu, assembly 1, side view.
Fibroblast growth factor 23 N-terminal peptide in PDB entry 7ysu, assembly 1, top view.
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