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Crystal structure of the human leptin:LepR-CRH2 encounter complex to 3.6 A resolution.

X-ray diffraction
3.617Å resolution
PDB entry 7z3q coloured by chain, front view.
PDB entry 7z3q coloured by chain, side view.
PDB entry 7z3q coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Leptin receptor and Leptin
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Multimeric state: hetero dimer
Accessible surface area: 15903.38 Å2
Buried surface area: 1620.77 Å2
Dissociation area: 810.38 Å2
Dissociation energy (ΔGdiss): -0.2 kcal/mol
Dissociation entropy (TΔSdiss): 11.37 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-273702
Assembly 2 (preferred)
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Assembly Name: Leptin receptor and Leptin
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Multimeric state: hetero dimer
Accessible surface area: 16827.09 Å2
Buried surface area: 1580.83 Å2
Dissociation area: 790.42 Å2
Dissociation energy (ΔGdiss): -1.26 kcal/mol
Dissociation entropy (TΔSdiss): 11.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-273702
Assembly 3
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Assembly Name: Leptin receptor and Leptin
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Multimeric state: hetero dimer
Accessible surface area: 16107.71 Å2
Buried surface area: 1675.37 Å2
Dissociation area: 837.68 Å2
Dissociation energy (ΔGdiss): -1.58 kcal/mol
Dissociation entropy (TΔSdiss): 11.48 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-273702

Macromolecules

Leptin
Chains: A, C, E
Length: 171 amino acids
Theoretical weight: 18.61 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P41159 (Residues: 22-167; Coverage: 100%)
Gene names: LEP, OB, OBS
Pfam: Leptin
InterPro:
Leptin in PDB entry 7z3q, assembly 2, front view.
Leptin in PDB entry 7z3q, assembly 2, side view.
Leptin in PDB entry 7z3q, assembly 2, top view.
PDBe-KB: UniProt Coverage View: P41159  
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Leptin receptor
Chains: B, D, F
Length: 232 amino acids
Theoretical weight: 26.12 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P48357 (Residues: 428-635; Coverage: 18%)
Gene names: DB, LEPR, OBR
Pfam: Obesity receptor immunoglobulin like domain
InterPro:
Leptin receptor in PDB entry 7z3q, assembly 2, front view.
Leptin receptor in PDB entry 7z3q, assembly 2, side view.
Leptin receptor in PDB entry 7z3q, assembly 2, top view.
PDBe-KB: UniProt Coverage View: P48357  
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