8ox6

Electron Microscopy
2.39Å resolution

Cryo-EM structure of ATP8B1-CDC50A in E1P conformation

Released:

Function and Biology Details

Reaction catalysed:
ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2)

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-128957 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Phospholipid-transporting ATPase IC Chain: A
Molecule details ›
Chain: A
Length: 1185 amino acids
Theoretical weight: 136.28 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: O43520 (Residues: 1-1185; Coverage: 95%)
Gene names: ATP8B1, ATPIC, FIC1, PFIC
Sequence domains:
Cell cycle control protein 50A Chain: B
Molecule details ›
Chain: B
Length: 365 amino acids
Theoretical weight: 41.09 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: Q9NV96 (Residues: 1-361; Coverage: 100%)
Gene names: C6orf67, CDC50A, TMEM30A
Sequence domains: LEM3 (ligand-effect modulator 3) family / CDC50 family

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.39Å
Relevant EMDB volumes: EMD-17258
Expression system: Saccharomyces cerevisiae