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Human Sirt6 in complex with ADP-ribose and fragment nicotinamide

X-ray diffraction
1.82Å resolution
PDB entry 8ake coloured by chain, front view.
PDB entry 8ake coloured by chain, side view.
PDB entry 8ake coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: NAD-dependent protein deacylase sirtuin-6
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Multimeric state: monomeric
Accessible surface area: 14002.56 Å2
Buried surface area: 1203.14 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-185425
Assembly 2
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Assembly Name: NAD-dependent protein deacylase sirtuin-6
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Multimeric state: monomeric
Accessible surface area: 13472.84 Å2
Buried surface area: 609.65 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-185425

Macromolecules

NAD-dependent protein deacylase sirtuin-6
Chains: A, B
Length: 302 amino acids
Theoretical weight: 33.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8N6T7 (Residues: 13-308; Coverage: 83%)
Gene names: SIR2L6, SIRT6
Pfam: Sir2 family
NAD-dependent protein deacylase sirtuin-6 in PDB entry 8ake, assembly 1, front view.
NAD-dependent protein deacylase sirtuin-6 in PDB entry 8ake, assembly 1, side view.
NAD-dependent protein deacylase sirtuin-6 in PDB entry 8ake, assembly 1, top view.
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