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Cryo-EM structure of MLE in complex with ADP:AlF4 and U10 RNA

Electron Microscopy
2.86Å resolution
PDB entry 8b9g coloured by chain, front view.
PDB entry 8b9g coloured by chain, side view.
PDB entry 8b9g coloured by chain, top view.
Source organism: Drosophila melanogaster
Assembly composition:
hetero dimer (preferred)
Entry contents: 1 distinct polypeptide molecule
1 distinct RNA molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Dosage compensation regulator mle and RNA
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Multimeric state: hetero dimer
Accessible surface area: 39077.12 Å2
Buried surface area: 4362.4 Å2
Dissociation area: 1,621.27 Å2
Dissociation energy (ΔGdiss): 41.75 kcal/mol
Dissociation entropy (TΔSdiss): 10.21 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-232451

Macromolecules

Dosage compensation regulator mle
Chain: A
Length: 1159 amino acids
Theoretical weight: 130.47 KDa
Source organism: Drosophila melanogaster
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P24785 (Residues: 1-1159; Coverage: 90%)
Gene names: CG11680, mle, nap
Pfam:
Dosage compensation regulator mle in PDB entry 8b9g, assembly 1, front view.
Dosage compensation regulator mle in PDB entry 8b9g, assembly 1, side view.
Dosage compensation regulator mle in PDB entry 8b9g, assembly 1, top view.
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RNA chain C
Name: RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3')
Representative chains: C
Source organism: Drosophila melanogaster [7227]
Expression system: Not provided
Length: 10 nucleotides
Theoretical weight: 3.02 KDa
RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') in PDB entry 8b9g, assembly 1, front view.
RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') in PDB entry 8b9g, assembly 1, side view.
RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') in PDB entry 8b9g, assembly 1, top view.
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