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Cryo-EM structure of human CLCF1 signaling complex: model containing the interaction core region

Electron Microscopy
3.9Å resolution
PDB entry 8d7r coloured by chain, front view.
PDB entry 8d7r coloured by chain, side view.
PDB entry 8d7r coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 67768.88 Å2
Buried surface area: 8584.9 Å2
Dissociation area: 2,572.5 Å2
Dissociation energy (ΔGdiss): -11.46 kcal/mol
Dissociation entropy (TΔSdiss): 41.73 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150896

Macromolecules

Cardiotrophin-like cytokine factor 1
Chain: D
Length: 204 amino acids
Theoretical weight: 23.12 KDa
Source organism: Homo sapiens
Expression system: Mus musculus
UniProt:
  • Canonical: Q9UBD9 (Residues: 28-225; Coverage: 100%)
Gene names: BSF3, CLC, CLCF1, NNT1
Pfam: Plethodontid receptivity factor PRF
InterPro:
Cardiotrophin-like cytokine factor 1 in PDB entry 8d7r, assembly 1, front view.
Cardiotrophin-like cytokine factor 1 in PDB entry 8d7r, assembly 1, side view.
Cardiotrophin-like cytokine factor 1 in PDB entry 8d7r, assembly 1, top view.
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Ciliary neurotrophic factor receptor subunit alpha
Chain: C
Length: 324 amino acids
Theoretical weight: 36.12 KDa
Source organism: Homo sapiens
Expression system: Mus musculus
UniProt:
  • Canonical: P26992 (Residues: 23-346; Coverage: 93%)
Gene name: CNTFR
Pfam: Fibronectin type III domain
InterPro:
Ciliary neurotrophic factor receptor subunit alpha in PDB entry 8d7r, assembly 1, front view.
Ciliary neurotrophic factor receptor subunit alpha in PDB entry 8d7r, assembly 1, side view.
Ciliary neurotrophic factor receptor subunit alpha in PDB entry 8d7r, assembly 1, top view.
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Leukemia inhibitory factor receptor
Chain: B
Length: 817 amino acids
Theoretical weight: 92.83 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P42702 (Residues: 45-833; Coverage: 75%)
Gene name: LIFR
Pfam:
InterPro:
Leukemia inhibitory factor receptor in PDB entry 8d7r, assembly 1, front view.
Leukemia inhibitory factor receptor in PDB entry 8d7r, assembly 1, side view.
Leukemia inhibitory factor receptor in PDB entry 8d7r, assembly 1, top view.
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Interleukin-6 receptor subunit beta
Chain: A
Length: 625 amino acids
Theoretical weight: 71.23 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P40189 (Residues: 23-619; Coverage: 67%)
  • Best match: P40189-2 (Residues: 23-324)
Gene name: IL6ST
Pfam:
InterPro:
Interleukin-6 receptor subunit beta in PDB entry 8d7r, assembly 1, front view.
Interleukin-6 receptor subunit beta in PDB entry 8d7r, assembly 1, side view.
Interleukin-6 receptor subunit beta in PDB entry 8d7r, assembly 1, top view.
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