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Structure of p110 gamma bound to the Ras inhibitory nanobody NB7

Electron Microscopy
2.96Å resolution
PDB entry 8dp0 coloured by chain, front view.
PDB entry 8dp0 coloured by chain, side view.
PDB entry 8dp0 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform and IG-heavy chain
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Multimeric state: hetero dimer
Accessible surface area: 46643.05 Å2
Buried surface area: 2438.71 Å2
Dissociation area: 1,219.36 Å2
Dissociation energy (ΔGdiss): 3.93 kcal/mol
Dissociation entropy (TΔSdiss): 12.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-225664

Macromolecules

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Chain: A
Length: 1102 amino acids
Theoretical weight: 126.63 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P48736 (Residues: 1-1102; Coverage: 100%)
Gene name: PIK3CG
Pfam:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform in PDB entry 8dp0, assembly 1, front view.
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform in PDB entry 8dp0, assembly 1, side view.
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform in PDB entry 8dp0, assembly 1, top view.
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Nanobody NB7
Chain: B
Length: 136 amino acids
Theoretical weight: 14.57 KDa
Source organism: Lama glama
Expression system: Escherichia coli
Nanobody NB7 in PDB entry 8dp0, assembly 1, front view.
Nanobody NB7 in PDB entry 8dp0, assembly 1, side view.
Nanobody NB7 in PDB entry 8dp0, assembly 1, top view.
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