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ZBTB7A Zinc Finger Domain Bound to DNA Duplex Containing CAST sequence (#10)

X-ray diffraction
2.99Å resolution
PDB entry 8e3e coloured by chain, front view.
PDB entry 8e3e coloured by chain, side view.
PDB entry 8e3e coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct DNA molecules

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Assemblies

Assembly 1
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Assembly Name: Zinc finger and BTB domain-containing protein 7A and DNA
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Multimeric state: hetero trimer
Accessible surface area: 13021.86 Å2
Buried surface area: 4988.2 Å2
Dissociation area: 1,615.86 Å2
Dissociation energy (ΔGdiss): 31.96 kcal/mol
Dissociation entropy (TΔSdiss): 11.98 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-512629
Assembly 2 (preferred)
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Assembly Name: Zinc finger and BTB domain-containing protein 7A and DNA
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Multimeric state: hetero trimer
Accessible surface area: 13071.25 Å2
Buried surface area: 4941.8 Å2
Dissociation area: 1,600.66 Å2
Dissociation energy (ΔGdiss): 33.19 kcal/mol
Dissociation entropy (TΔSdiss): 11.93 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-512629
Assembly 3
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Assembly Name: Zinc finger and BTB domain-containing protein 7A and DNA
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Multimeric state: hetero trimer
Accessible surface area: 13834.82 Å2
Buried surface area: 5108.22 Å2
Dissociation area: 1,670.88 Å2
Dissociation energy (ΔGdiss): 25.39 kcal/mol
Dissociation entropy (TΔSdiss): 12.07 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-512629

Macromolecules

Zinc finger and BTB domain-containing protein 7A
Chains: A, B, F
Length: 165 amino acids
Theoretical weight: 19.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O95365 (Residues: 341-505; Coverage: 28%)
Gene names: FBI1, LRF, ZBTB7, ZBTB7A, ZNF857A
Pfam: Zinc finger, C2H2 type
InterPro:
Zinc finger and BTB domain-containing protein 7A in PDB entry 8e3e, assembly 2, front view.
Zinc finger and BTB domain-containing protein 7A in PDB entry 8e3e, assembly 2, side view.
Zinc finger and BTB domain-containing protein 7A in PDB entry 8e3e, assembly 2, top view.
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DNA chains D, H, X
Name: DNA (5'-D(*CP*TP*TP*TP*GP*GP*GP*GP*AP*GP*GP*GP*GP*TP*CP*TP*TP*TP*TP*AP*C)-3')
Representative chains: D, H, X
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 21 nucleotides
Theoretical weight: 6.52 KDa
DNA (5'-D(*CP*TP*TP*TP*GP*GP*GP*GP*AP*GP*GP*GP*GP*TP*CP*TP*TP*TP*TP*AP*C)-3') in PDB entry 8e3e, assembly 2, front view.
DNA (5'-D(*CP*TP*TP*TP*GP*GP*GP*GP*AP*GP*GP*GP*GP*TP*CP*TP*TP*TP*TP*AP*C)-3') in PDB entry 8e3e, assembly 2, side view.
DNA (5'-D(*CP*TP*TP*TP*GP*GP*GP*GP*AP*GP*GP*GP*GP*TP*CP*TP*TP*TP*TP*AP*C)-3') in PDB entry 8e3e, assembly 2, top view.
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DNA chains E, I, Y
Name: DNA (5'-D(*GP*GP*TP*AP*AP*AP*AP*GP*AP*CP*CP*CP*CP*TP*CP*CP*CP*CP*AP*AP*A)-3')
Representative chains: E, I, Y
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 21 nucleotides
Theoretical weight: 6.37 KDa
DNA (5'-D(*GP*GP*TP*AP*AP*AP*AP*GP*AP*CP*CP*CP*CP*TP*CP*CP*CP*CP*AP*AP*A)-3') in PDB entry 8e3e, assembly 2, front view.
DNA (5'-D(*GP*GP*TP*AP*AP*AP*AP*GP*AP*CP*CP*CP*CP*TP*CP*CP*CP*CP*AP*AP*A)-3') in PDB entry 8e3e, assembly 2, side view.
DNA (5'-D(*GP*GP*TP*AP*AP*AP*AP*GP*AP*CP*CP*CP*CP*TP*CP*CP*CP*CP*AP*AP*A)-3') in PDB entry 8e3e, assembly 2, top view.
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