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Rabbit L-type voltage-gated calcium channel Cav1.1 in the presence of Amiodarone and 1 mM MNI-1 at 3.0 Angstrom resolution

Electron Microscopy
3Å resolution
PDB entry 8e58 coloured by chain, front view.
PDB entry 8e58 coloured by chain, side view.
PDB entry 8e58 coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Voltage-dependent calcium channel
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Multimeric state: hetero trimer
Accessible surface area: 108141.3 Å2
Buried surface area: 12269.4 Å2
Dissociation area: 1,563.58 Å2
Dissociation energy (ΔGdiss): 17.19 kcal/mol
Dissociation entropy (TΔSdiss): 13.76 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139486

Macromolecules

Voltage-dependent L-type calcium channel subunit alpha-1S
Chain: A
Length: 1873 amino acids
Theoretical weight: 212.24 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P07293 (Residues: 1-1873; Coverage: 100%)
Gene names: CACH1, CACNA1S, CACNL1A3
Pfam:
InterPro:
Voltage-dependent L-type calcium channel subunit alpha-1S in PDB entry 8e58, assembly 1, front view.
Voltage-dependent L-type calcium channel subunit alpha-1S in PDB entry 8e58, assembly 1, side view.
Voltage-dependent L-type calcium channel subunit alpha-1S in PDB entry 8e58, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P07293  
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Voltage-dependent calcium channel gamma-1 subunit
Chain: E
Length: 222 amino acids
Theoretical weight: 25.08 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P19518 (Residues: 1-222; Coverage: 100%)
Gene names: CACNG1, CACNLG
Pfam: PMP-22/EMP/MP20/Claudin tight junction
InterPro:
Voltage-dependent calcium channel gamma-1 subunit in PDB entry 8e58, assembly 1, front view.
Voltage-dependent calcium channel gamma-1 subunit in PDB entry 8e58, assembly 1, side view.
Voltage-dependent calcium channel gamma-1 subunit in PDB entry 8e58, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P19518  
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Voltage-dependent calcium channel subunit alpha-2/delta-1
Chain: F
Length: 1106 amino acids
Theoretical weight: 125.17 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P13806 (Residues: 1-1106; Coverage: 100%)
Gene names: CACNA2D1, CACNL2A, CCHL2A
Pfam:
InterPro:
Voltage-dependent calcium channel subunit alpha-2/delta-1 in PDB entry 8e58, assembly 1, front view.
Voltage-dependent calcium channel subunit alpha-2/delta-1 in PDB entry 8e58, assembly 1, side view.
Voltage-dependent calcium channel subunit alpha-2/delta-1 in PDB entry 8e58, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P13806  
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