› 8fd7

Electron Microscopy
3.1Å resolution

Structure of the human L-type voltage-gated calcium channel Cav1.2 complexed with gabapentin

Released:
DOI: 10.2210/pdb8fd7/pdb
PDB entry 8fd7 coloured by chain, front view.
PDB entry 8fd7 coloured by chain, side view.
PDB entry 8fd7 coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis for CaVα2δ:gabapentin binding.
Chen Z, Mondal A, Minor DL
Nat Struct Mol Biol (2023)
PMID: 36973510
Related structures: EMD-29004

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146771 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Voltage-dependent calcium channel subunit alpha-2/delta-1 Chain: D
Molecule details ›
Chain: D
Length: 1105 amino acids
Theoretical weight: 125.08 KDa
Source organism: Oryctolagus cuniculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P13806 (Residues: 1-1106; Coverage: 100%)
Gene names: CACNA2D1, CACNL2A, CCHL2A
Sequence domains:
Voltage-dependent L-type calcium channel subunit alpha-1C Chain: K
Molecule details ›
Chain: K
Length: 1648 amino acids
Theoretical weight: 187.08 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q13936 (Residues: 1-1696; Coverage: 74%)
  • Best match: Q13936-12 (Residues: 1-1648)
Gene names: CACH2, CACN2, CACNA1C, CACNL1A1, CCHL1A1
Sequence domains:
Voltage-dependent L-type calcium channel subunit beta-3 Chain: C
Molecule details ›
Chain: C
Length: 477 amino acids
Theoretical weight: 53.89 KDa
Source organism: Oryctolagus cuniculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P54286 (Residues: 1-477; Coverage: 100%)
Gene names: CACNB3, CACNLB3
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
7 bound ligands:
Ligand NAG 8 x NAG
Ligand GBN 1 x GBN
Ligand CA 3 x CA
Ligand NA 1 x NA
Ligand WO9 1 x WO9
Ligand YSW 1 x YSW
Ligand CLR 3 x CLR
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-29004
Expression system: Homo sapiens

Quick links

Citations

2 citation in other articles

Origin and functional diversification of PAS domain, a ubiquitous intracellular sensor.
Xing et al. (2023)
1 more

2 mentions without citation

Structural biology of voltage-gated calcium channels.
Yao et al. (2024)
1 more