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Structure of the human L-type voltage-gated calcium channel Cav1.2 complexed with gabapentin

Electron Microscopy
3.1Å resolution
PDB entry 8fd7 coloured by chain, front view.
PDB entry 8fd7 coloured by chain, side view.
PDB entry 8fd7 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Voltage-dependent calcium channel
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Multimeric state: hetero trimer
Accessible surface area: 121853.77 Å2
Buried surface area: 8570.88 Å2
Dissociation area: 1,840.48 Å2
Dissociation energy (ΔGdiss): -0.31 kcal/mol
Dissociation entropy (TΔSdiss): 29.83 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-146771

Macromolecules

Voltage-dependent calcium channel subunit alpha-2/delta-1
Chain: D
Length: 1105 amino acids
Theoretical weight: 125.08 KDa
Source organism: Oryctolagus cuniculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P13806 (Residues: 1-1106; Coverage: 100%)
Gene names: CACNA2D1, CACNL2A, CCHL2A
Pfam:
InterPro:
Voltage-dependent calcium channel subunit alpha-2/delta-1 in PDB entry 8fd7, assembly 1, front view.
Voltage-dependent calcium channel subunit alpha-2/delta-1 in PDB entry 8fd7, assembly 1, side view.
Voltage-dependent calcium channel subunit alpha-2/delta-1 in PDB entry 8fd7, assembly 1, top view.
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Voltage-dependent L-type calcium channel subunit alpha-1C
Chain: K
Length: 1648 amino acids
Theoretical weight: 187.08 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q13936 (Residues: 1-1696; Coverage: 74%)
  • Best match: Q13936-12 (Residues: 1-1648)
Gene names: CACH2, CACN2, CACNA1C, CACNL1A1, CCHL1A1
Pfam:
InterPro:
Voltage-dependent L-type calcium channel subunit alpha-1C in PDB entry 8fd7, assembly 1, front view.
Voltage-dependent L-type calcium channel subunit alpha-1C in PDB entry 8fd7, assembly 1, side view.
Voltage-dependent L-type calcium channel subunit alpha-1C in PDB entry 8fd7, assembly 1, top view.
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Voltage-dependent L-type calcium channel subunit beta-3
Chain: C
Length: 477 amino acids
Theoretical weight: 53.89 KDa
Source organism: Oryctolagus cuniculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P54286 (Residues: 1-477; Coverage: 100%)
Gene names: CACNB3, CACNLB3
Pfam:
InterPro:
Voltage-dependent L-type calcium channel subunit beta-3 in PDB entry 8fd7, assembly 1, front view.
Voltage-dependent L-type calcium channel subunit beta-3 in PDB entry 8fd7, assembly 1, side view.
Voltage-dependent L-type calcium channel subunit beta-3 in PDB entry 8fd7, assembly 1, top view.
Molecule details ›

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