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Structure of the human L-type voltage-gated calcium channel Cav1.2 complexed with gabapentin

Source organisms:
Biochemical function: voltage-gated calcium channel activity
Biological process: calcium ion transmembrane transport
Cellular component: voltage-gated calcium channel complex

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF00520
Domain description: Ion transport protein
Occurring in:
  1. Voltage-dependent L-type calcium channel subunit alpha-1C
The deposited structure of PDB entry 8fd7 contains 6 copies of Pfam domain PF00520 (Ion transport protein) in Voltage-dependent L-type calcium channel subunit alpha-1C. Showing 6 copies in chain B [auth K].

PF08763
Domain description: Voltage gated calcium channel IQ domain
Occurring in:
  1. Voltage-dependent L-type calcium channel subunit alpha-1C
The deposited structure of PDB entry 8fd7 contains 1 copy of Pfam domain PF08763 (Voltage gated calcium channel IQ domain) in Voltage-dependent L-type calcium channel subunit alpha-1C. Showing 1 copy in chain B [auth K].

PF16905
Domain description: Voltage-dependent L-type calcium channel, IQ-associated
Occurring in:
  1. Voltage-dependent L-type calcium channel subunit alpha-1C
The deposited structure of PDB entry 8fd7 contains 1 copy of Pfam domain PF16905 (Voltage-dependent L-type calcium channel, IQ-associated) in Voltage-dependent L-type calcium channel subunit alpha-1C. Showing 1 copy in chain B [auth K].

PF08016
Domain description: Polycystin cation channel
Occurring in:
  1. Voltage-dependent L-type calcium channel subunit alpha-1C

PF08473
Domain description: Neuronal voltage-dependent calcium channel alpha 2acd
Occurring in:
  1. Voltage-dependent calcium channel subunit alpha-2/delta-1
The deposited structure of PDB entry 8fd7 contains 1 copy of Pfam domain PF08473 (Neuronal voltage-dependent calcium channel alpha 2acd) in Voltage-dependent calcium channel subunit alpha-2/delta-1. Showing 1 copy in chain A [auth D].

PF00092
Domain description: von Willebrand factor type A domain
Occurring in:
  1. Voltage-dependent calcium channel subunit alpha-2/delta-1

PF08399
Domain description: VWA N-terminal
Occurring in:
  1. Voltage-dependent calcium channel subunit alpha-2/delta-1
The deposited structure of PDB entry 8fd7 contains 1 copy of Pfam domain PF08399 (VWA N-terminal) in Voltage-dependent calcium channel subunit alpha-2/delta-1. Showing 1 copy in chain A [auth D].

PF00625
Domain description: Guanylate kinase
Occurring in:
  1. Voltage-dependent L-type calcium channel subunit beta-3
The deposited structure of PDB entry 8fd7 contains 1 copy of Pfam domain PF00625 (Guanylate kinase) in Voltage-dependent L-type calcium channel subunit beta-3. Showing 1 copy in chain C.

PF12052
Domain description: Voltage gated calcium channel subunit beta domain 4Aa N terminal
Occurring in:
  1. Voltage-dependent L-type calcium channel subunit beta-3
The deposited structure of PDB entry 8fd7 contains 1 copy of Pfam domain PF12052 (Voltage gated calcium channel subunit beta domain 4Aa N terminal) in Voltage-dependent L-type calcium channel subunit beta-3. Showing 1 copy in chain C (this domain is out of the observed residue ranges!).

InterPro InterPro annotations
IPR000584
Domain description: Voltage-dependent calcium channel, L-type, beta subunit
Occurring in:
  1. Voltage-dependent L-type calcium channel subunit beta-3
IPR002077
Domain description: Voltage-dependent calcium channel, alpha-1 subunit
Occurring in:
  1. Voltage-dependent L-type calcium channel subunit alpha-1C
IPR005451
Domain description: Voltage-dependent calcium channel, L-type, alpha-1C subunit
Occurring in:
  1. Voltage-dependent L-type calcium channel subunit alpha-1C
IPR005446
Domain description: Voltage-dependent calcium channel, L-type, alpha-1 subunit
Occurring in:
  1. Voltage-dependent L-type calcium channel subunit alpha-1C
IPR005821
Domain description: Ion transport domain
Occurring in:
  1. Voltage-dependent L-type calcium channel subunit alpha-1C
IPR027359
Domain description: Voltage-dependent channel domain superfamily
Occurring in:
  1. Voltage-dependent L-type calcium channel subunit alpha-1C
IPR008079
Domain description: Voltage-dependent calcium channel, L-type, beta-3 subunit
Occurring in:
  1. Voltage-dependent L-type calcium channel subunit beta-3
IPR002035
Domain description: von Willebrand factor, type A
Occurring in:
  1. Voltage-dependent calcium channel subunit alpha-2/delta-1
IPR014873
Domain description: Voltage-dependent calcium channel, alpha-1 subunit, IQ domain
Occurring in:
  1. Voltage-dependent L-type calcium channel subunit alpha-1C
IPR036465
Domain description: von Willebrand factor A-like domain superfamily
Occurring in:
  1. Voltage-dependent calcium channel subunit alpha-2/delta-1
IPR008145
Domain description: Guanylate kinase/L-type calcium channel beta subunit
Occurring in:
  1. Voltage-dependent L-type calcium channel subunit beta-3
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Voltage-dependent L-type calcium channel subunit beta-3
IPR031649
Domain description: Voltage-dependent L-type calcium channel, IQ-associated domain
Occurring in:
  1. Voltage-dependent L-type calcium channel subunit alpha-1C
IPR013680
Domain description: Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region
Occurring in:
  1. Voltage-dependent calcium channel subunit alpha-2/delta-1
IPR013608
Domain description: VWA N-terminal
Occurring in:
  1. Voltage-dependent calcium channel subunit alpha-2/delta-1
IPR001452
Domain description: SH3 domain
Occurring in:
  1. Voltage-dependent L-type calcium channel subunit beta-3
IPR035760
Domain description: Voltage-dependent L-type calcium channel subunit beta-3, SH3 domain
Occurring in:
  1. Voltage-dependent L-type calcium channel subunit beta-3
IPR036028
Domain description: SH3-like domain superfamily
Occurring in:
  1. Voltage-dependent L-type calcium channel subunit beta-3
IPR046937
Domain description: Voltage-dependent L-type calcium channel subunit beta-1-4, N-terminal A domain
Occurring in:
  1. Voltage-dependent L-type calcium channel subunit beta-3

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