› › Structure analysis

Erythromycin bound Klebsiella pneumoniae AcrB multidrug efflux pump

Electron Microscopy
2.96Å resolution
PDB entry 8ffs coloured by chain, front view.
PDB entry 8ffs coloured by chain, side view.
PDB entry 8ffs coloured by chain, top view.
Source organism: Klebsiella pneumoniae
Assembly composition:
homo trimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Efflux pump membrane transporter
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Multimeric state: homo trimer
Accessible surface area: 109538.41 Å2
Buried surface area: 19830.28 Å2
Dissociation area: 6,095.73 Å2
Dissociation energy (ΔGdiss): 66.13 kcal/mol
Dissociation entropy (TΔSdiss): 17.96 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-215265

Macromolecules

Efflux pump membrane transporter
Chains: A, B, C
Length: 1048 amino acids
Theoretical weight: 113.4 KDa
Source organism: Klebsiella pneumoniae
Expression system: Escherichia coli
UniProt:
  • Canonical: W9B4M6 (Residues: 1-1048; Coverage: 100%)
Gene names: B5L96_25060, B6I68_14245, BANRA_03961, BL124_00005200, EAO17_20125, G4V31_01305, GJD52_19690, GJJ08_020700, GJJ18_13925, IMY55_19950, KPZU09_34270, LS45_03030, NCTC5052_00390, QIG75_10355, SAMEA104216642_04010, SAMEA3499874_02421, SAMEA3499901_01083, SAMEA3512100_02852, SAMEA3515122_00719, SAMEA3538424_01568, SAMEA3538658_03115, SAMEA3538828_00630, SAMEA3649591_01590, SAMEA3649615_01319, SAMEA3727706_02433, SAMEA4364603_02893, SAMEA4370542_02341, SAMEA4873597_02682, SAMEA4873632_02671, VKR_03842, acrB, acrB_1, acrB_2, acrB_3, acrB_4
Pfam: AcrB/AcrD/AcrF family
InterPro:
Efflux pump membrane transporter in PDB entry 8ffs, assembly 1, front view.
Efflux pump membrane transporter in PDB entry 8ffs, assembly 1, side view.
Efflux pump membrane transporter in PDB entry 8ffs, assembly 1, top view.
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