Structure analysis

60S subunit of the Giardia lamblia 80S ribosome

Electron Microscopy
2.49Å resolution
Assembly composition:
hetero 43-mer (preferred)
Entry contents: 40 distinct polypeptide molecules
3 distinct RNA molecules

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Multimeric state: hetero 43-mer
Accessible surface area: 564733.41 Å2
Buried surface area: 320644.73 Å2
Dissociation area: 24.9 Å2
Dissociation energy (ΔGdiss): -7.19 kcal/mol
Dissociation entropy (TΔSdiss): 8.36 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-275642

Macromolecules

Chain: B
Length: 379 amino acids
Theoretical weight: 42.69 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: V6TF11 (Residues: 1-379; Coverage: 100%)
Gene name: DHA2_16525
Pfam: Ribosomal protein L3

Search similar proteins

Chain: a
Length: 149 amino acids
Theoretical weight: 17.17 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: A8BZ78 (Residues: 1-149; Coverage: 100%)
Gene name: GL50803_0016310
Pfam: Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A

Search similar proteins

Chain: C
Length: 316 amino acids
Theoretical weight: 35.05 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: A8B7H8 (Residues: 1-316; Coverage: 100%)
Gene name: GL50803_0017547
Pfam:

Search similar proteins

Chain: I
Length: 210 amino acids
Theoretical weight: 24.28 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: A8BM86 (Residues: 1-210; Coverage: 100%)
Gene name: GL50803_0010428
Pfam: Ribosomal protein L16p/L10e

Search similar proteins

Chain: p
Length: 94 amino acids
Theoretical weight: 10.51 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: A8BN26 (Residues: 1-94; Coverage: 100%)
Gene name: GL50803_005517
Pfam: Ribosomal L37ae protein family

Search similar proteins

Chain: D
Length: 297 amino acids
Theoretical weight: 33.96 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: E2RU47 (Residues: 1-297; Coverage: 100%)
Gene name: GL50803_0017395
Pfam:

Search similar proteins

Chain: H
Length: 185 amino acids
Theoretical weight: 20.89 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: A8BNT5 (Residues: 1-185; Coverage: 100%)
Gene name: GL50803_0017056
Pfam: Ribosomal protein L6

Search similar proteins

Chain: G
Length: 225 amino acids
Theoretical weight: 25.43 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: A8BLL7 (Residues: 1-225; Coverage: 100%)
Gene name: GL50803_0017244
Pfam: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

Search similar proteins

Chain: J
Length: 173 amino acids
Theoretical weight: 19.77 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: A8BI95 (Residues: 1-173; Coverage: 100%)
Gene name: GL50803_005593
Pfam:

Search similar proteins

Chain: O
Length: 197 amino acids
Theoretical weight: 22.92 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: A8BU75 (Residues: 1-197; Coverage: 100%)
Gene name: GL50803_0011247
Pfam: Ribosomal protein L13

Search similar proteins

Chain: L
Length: 234 amino acids
Theoretical weight: 26.64 KDa
Source organism: Giardia intestinalis assemblage A

Search similar proteins

Chain: M
Length: 131 amino acids
Theoretical weight: 14.79 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: A8B4F8 (Residues: 1-131; Coverage: 100%)
Gene name: GL50803_0014091
Pfam: Ribosomal protein L14

Search similar proteins

Chain: N
Length: 204 amino acids
Theoretical weight: 24.35 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: A8B8Z6 (Residues: 1-204; Coverage: 100%)
Gene name: GL50803_008001
Pfam: Ribosomal L15

Search similar proteins

Chain: Q
Length: 179 amino acids
Theoretical weight: 20.21 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: A8B4T7 (Residues: 1-179; Coverage: 100%)
Gene name: GL50803_0011950
Pfam: Ribosomal protein 60S L18 and 50S L18e

Search similar proteins

Chain: S
Length: 205 amino acids
Theoretical weight: 24.39 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: V6TB90 (Residues: 1-205; Coverage: 100%)
Gene name: DHA2_16387
Pfam: Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A

Search similar proteins

Chain: R
Length: 196 amino acids
Theoretical weight: 23.2 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: A8BH61 (Residues: 1-196; Coverage: 100%)
Gene name: GL50803_0016431
Pfam: Ribosomal protein L19e

Search similar proteins

Chain: T
Length: 159 amino acids
Theoretical weight: 18.3 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: A8B2Q4 (Residues: 1-159; Coverage: 100%)
Gene name: GL50803_0015520
Pfam: Ribosomal protein L21e

Search similar proteins

Chain: V
Length: 142 amino acids
Theoretical weight: 15.45 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: A8BS37 (Residues: 1-142; Coverage: 100%)
Gene name: GL50803_0010091
Pfam: Ribosomal protein L14p/L23e

Search similar proteins

Chain: P
Length: 164 amino acids
Theoretical weight: 18.72 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: A8BE76 (Residues: 1-164; Coverage: 100%)
Gene name: GL50803_0098056
Pfam: Ribosomal protein L22p/L17e

Search similar proteins

Chain: X
Length: 141 amino acids
Theoretical weight: 16.05 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: A8BMP6 (Residues: 1-141; Coverage: 100%)
Gene name: GL50803_007870
Pfam:

Search similar proteins

Chain: Y
Length: 135 amino acids
Theoretical weight: 15.62 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: V6TD19 (Residues: 17-151; Coverage: 89%)
Gene name: DHA2_15046
Pfam: Ribosomal proteins L26 eukaryotic, L24P archaeal

Search similar proteins

Chain: W
Length: 102 amino acids
Theoretical weight: 12.01 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: A8BRH7 (Residues: 1-102; Coverage: 100%)
Gene name: GL50803_0019003
Pfam: Ribosomal protein L24e

Search similar proteins

Chain: Z
Length: 135 amino acids
Theoretical weight: 15.37 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: A8B1T3 (Residues: 1-135; Coverage: 100%)
Gene name: GL50803_008462
Pfam:

Search similar proteins

Chain: b
Length: 62 amino acids
Theoretical weight: 7.36 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: V6TAA6 (Residues: 14-75; Coverage: 83%)
Gene name: DHA2_14457
Pfam: Ribosomal L29e protein family

Search similar proteins

Chain: h
Length: 124 amino acids
Theoretical weight: 14.32 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: A0A132NRN1 (Residues: 1-124; Coverage: 100%)
Gene name: QR46_3636
Pfam: Ribosomal L29 protein

Search similar proteins

Chain: F
Length: 235 amino acids
Theoretical weight: 27.1 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: A8BRY6 (Residues: 1-235; Coverage: 100%)
Gene name: GL50803_0019436
Pfam: Ribosomal protein L30p/L7e

Search similar proteins

Chain: d
Length: 106 amino acids
Theoretical weight: 12.18 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: A8BMP3 (Residues: 1-106; Coverage: 100%)
Gene name: GL50803_0016368
Pfam: Ribosomal protein L31e

Search similar proteins

Chain: e
Length: 136 amino acids
Theoretical weight: 15.99 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: A8BMD9 (Residues: 1-136; Coverage: 100%)
Gene name: GL50803_0014049
Pfam: Ribosomal protein L32

Search similar proteins

Chain: g
Length: 120 amino acids
Theoretical weight: 13.53 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: A8BMF7 (Residues: 1-120; Coverage: 100%)
Gene name: GL50803_0036069
Pfam: Ribosomal protein L34e

Search similar proteins

Chain: f
Length: 123 amino acids
Theoretical weight: 13.91 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: A8BKK5 (Residues: 1-123; Coverage: 100%)
Gene name: GL50803_005947
Pfam: Ribosomal protein L35Ae

Search similar proteins

Chain: i
Length: 90 amino acids
Theoretical weight: 10.59 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: A8BYA6 (Residues: 1-90; Coverage: 100%)
Gene name: GL50803_0016114
Pfam: Ribosomal protein L36e

Search similar proteins

Chain: k
Length: 77 amino acids
Theoretical weight: 8.61 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: A8B481 (Residues: 1-77; Coverage: 100%)
Gene name: GL50803_0034093
Pfam: Ribosomal L38e protein family

Search similar proteins

Chain: o
Length: 106 amino acids
Theoretical weight: 12.31 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: A8BQU8 (Residues: 1-106; Coverage: 100%)
Gene name: GL50803_009810
Pfam: Ribosomal protein L44

Search similar proteins

Chain: U
Length: 171 amino acids
Theoretical weight: 19.94 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: V6TJ98 (Residues: 1-171; Coverage: 100%)
Gene name: DHA2_16044
Pfam: Ribosomal L22e protein family

Search similar proteins

Chain: c
Length: 109 amino acids
Theoretical weight: 11.7 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: A8B5N7 (Residues: 1-109; Coverage: 100%)
Gene name: GL50803_0014321
Pfam: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

Search similar proteins

Chain: j
Length: 100 amino acids
Theoretical weight: 11.47 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: V6TG99 (Residues: 1-100; Coverage: 100%)
Gene name: DHA2_154535
Pfam: Ribosomal protein L37e

Search similar proteins

Chain: l
Length: 51 amino acids
Theoretical weight: 6.53 KDa
Source organism: Giardia intestinalis assemblage A

Search similar proteins

Chain: m
Length: 127 amino acids
Theoretical weight: 14.34 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: A8BXE1 (Residues: 1-127; Coverage: 100%)
Gene name: GL50803_005665
Pfam:

Search similar proteins

Chain: A
Length: 251 amino acids
Theoretical weight: 27.09 KDa
Source organism: Giardia intestinalis assemblage A
UniProt:
  • Canonical: E2RTN4 (Residues: 1-251; Coverage: 100%)
Gene name: GL50803_0016086
Pfam:

Search similar proteins

Name: 5S ribosomal RNA
Representative chains: 3
Length: 120 nucleotides
Theoretical weight: 38.67 KDa
Rfam: 5S ribosomal RNA

Search similar RNA

Name: 5.8S ribosomal RNA
Representative chains: 4
Length: 141 nucleotides
Theoretical weight: 45.59 KDa

Search similar RNA

Name: 28S ribosomal RNA
Representative chains: 1
Length: 2687 nucleotides
Theoretical weight: 871.35 KDa
Rfam: Eukaryotic large subunit ribosomal RNA

Search similar RNA