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Composite model of the yeast Hir Complex with Asf1/H3/H4

Electron Microscopy
2.96Å resolution
PDB entry 8ghn coloured by chain, front view.
PDB entry 8ghn coloured by chain, side view.
PDB entry 8ghn coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Assembly composition:
hetero pentadecamer (preferred)
Entry contents: 7 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentadecamer
Accessible surface area: 316585.84 Å2
Buried surface area: 87901.21 Å2
Dissociation area: 2,471.16 Å2
Dissociation energy (ΔGdiss): 4.09 kcal/mol
Dissociation entropy (TΔSdiss): 26.78 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-247639

Macromolecules

Protein HIR1
Chains: A, G
Length: 840 amino acids
Theoretical weight: 93.98 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
  • Canonical: P32479 (Residues: 1-840; Coverage: 100%)
Gene names: HIR1, YBL008W, YBL0318
Pfam:
Protein HIR1 in PDB entry 8ghn, assembly 1, front view.
Protein HIR1 in PDB entry 8ghn, assembly 1, side view.
Protein HIR1 in PDB entry 8ghn, assembly 1, top view.
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Protein HIR2
Chains: B, C, H, I
Length: 875 amino acids
Theoretical weight: 98.55 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
  • Canonical: P32480 (Residues: 1-875; Coverage: 100%)
Gene names: HIR2, OR26.31, YOR038C
Pfam: TUP1-like enhancer of split
Protein HIR2 in PDB entry 8ghn, assembly 1, front view.
Protein HIR2 in PDB entry 8ghn, assembly 1, side view.
Protein HIR2 in PDB entry 8ghn, assembly 1, top view.
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Histone transcription regulator 3
Chains: D, J
Length: 1648 amino acids
Theoretical weight: 191.92 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
  • Canonical: P47171 (Residues: 1-1648; Coverage: 100%)
Gene names: HIR3, HPC1, J2161, YJR140C
Histone transcription regulator 3 in PDB entry 8ghn, assembly 1, front view.
Histone transcription regulator 3 in PDB entry 8ghn, assembly 1, side view.
Histone transcription regulator 3 in PDB entry 8ghn, assembly 1, top view.
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Histone promoter control protein 2
Chains: E, F, K, L
Length: 625 amino acids
Theoretical weight: 67.88 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
  • Canonical: Q01448 (Residues: 1-625; Coverage: 100%)
Gene names: HPC2, YBR1503, YBR215W
Pfam: HPC2 and ubinuclein domain
Histone promoter control protein 2 in PDB entry 8ghn, assembly 1, front view.
Histone promoter control protein 2 in PDB entry 8ghn, assembly 1, side view.
Histone promoter control protein 2 in PDB entry 8ghn, assembly 1, top view.
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Histone H3
Chain: M
Length: 136 amino acids
Theoretical weight: 15.39 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: P61830 (Residues: 1-136; Coverage: 100%)
Gene names: HHT1, HHT2, N2749, SIN2, YBR010W, YBR0201, YNL031C
Pfam: Core histone H2A/H2B/H3/H4
Histone H3 in PDB entry 8ghn, assembly 1, front view.
Histone H3 in PDB entry 8ghn, assembly 1, side view.
Histone H3 in PDB entry 8ghn, assembly 1, top view.
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Histone H4
Chain: N
Length: 103 amino acids
Theoretical weight: 11.4 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: P02309 (Residues: 1-103; Coverage: 100%)
Gene names: HHF1, HHF2, N2752, YBR009C, YBR0122, YNL030W
Pfam: Centromere kinetochore component CENP-T histone fold
Histone H4 in PDB entry 8ghn, assembly 1, front view.
Histone H4 in PDB entry 8ghn, assembly 1, side view.
Histone H4 in PDB entry 8ghn, assembly 1, top view.
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Histone chaperone
Chain: O
Length: 279 amino acids
Theoretical weight: 31.63 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
Histone chaperone in PDB entry 8ghn, assembly 1, front view.
Histone chaperone in PDB entry 8ghn, assembly 1, side view.
Histone chaperone in PDB entry 8ghn, assembly 1, top view.
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