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Crystal structure of human cardiac alpha actin P109A mutant (ADP-Pi state) in complex with fragmin F1 domain

X-ray diffraction
1.5Å resolution
PDB entry 8gt3 coloured by chain, front view.
PDB entry 8gt3 coloured by chain, side view.
PDB entry 8gt3 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Actin, alpha cardiac muscle 1 and Gelsolin-like domain-containing protein
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Multimeric state: hetero dimer
Accessible surface area: 21193.02 Å2
Buried surface area: 6518.97 Å2
Dissociation area: 2,137.42 Å2
Dissociation energy (ΔGdiss): 21.49 kcal/mol
Dissociation entropy (TΔSdiss): 12.95 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-274132

Macromolecules

Actin, alpha cardiac muscle 1
Chain: A
Length: 391 amino acids
Theoretical weight: 43.62 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P68032 (Residues: 3-377; Coverage: 100%)
Gene names: ACTC, ACTC1
Pfam: Actin
InterPro:
Actin, alpha cardiac muscle 1 in PDB entry 8gt3, assembly 1, front view.
Actin, alpha cardiac muscle 1 in PDB entry 8gt3, assembly 1, side view.
Actin, alpha cardiac muscle 1 in PDB entry 8gt3, assembly 1, top view.
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Gelsolin-like domain-containing protein
Chain: B
Length: 162 amino acids
Theoretical weight: 18.25 KDa
Source organism: Physarum polycephalum
Expression system: Escherichia coli
UniProt:
  • Canonical: Q94707 (Residues: 1-160; Coverage: 43%)
Pfam: Gelsolin repeat
InterPro:
Gelsolin-like domain-containing protein in PDB entry 8gt3, assembly 1, front view.
Gelsolin-like domain-containing protein in PDB entry 8gt3, assembly 1, side view.
Gelsolin-like domain-containing protein in PDB entry 8gt3, assembly 1, top view.
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