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Cryo-EM structure of the human SAGA complex

Electron Microscopy
3.7Å resolution
PDB entry 8h7g coloured by chain, front view.
PDB entry 8h7g coloured by chain, side view.
PDB entry 8h7g coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetradecamer (preferred)
Entry contents: 14 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetradecamer
Accessible surface area: 325126.77 Å2
Buried surface area: 76414.89 Å2
Dissociation area: 1,583.6 Å2
Dissociation energy (ΔGdiss): -3.77 kcal/mol
Dissociation entropy (TΔSdiss): 17.65 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-279332

Macromolecules

Transformation/transcription domain-associated protein
Chain: C
Length: 3859 amino acids
Theoretical weight: 438.14 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y4A5 (Residues: 1-3859; Coverage: 100%)
Gene names: PAF400, TRRAP
Pfam:
InterPro:
Transformation/transcription domain-associated protein in PDB entry 8h7g, assembly 1, front view.
Transformation/transcription domain-associated protein in PDB entry 8h7g, assembly 1, side view.
Transformation/transcription domain-associated protein in PDB entry 8h7g, assembly 1, top view.
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Splicing factor 3B subunit 3
Chain: A
Length: 1217 amino acids
Theoretical weight: 135.72 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q15393 (Residues: 1-1217; Coverage: 100%)
Gene names: KIAA0017, SAP130, SF3B3
Pfam:
InterPro:
Splicing factor 3B subunit 3 in PDB entry 8h7g, assembly 1, front view.
Splicing factor 3B subunit 3 in PDB entry 8h7g, assembly 1, side view.
Splicing factor 3B subunit 3 in PDB entry 8h7g, assembly 1, top view.
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Splicing factor 3B subunit 5
Chain: B
Length: 86 amino acids
Theoretical weight: 10.15 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BWJ5 (Residues: 1-86; Coverage: 100%)
Gene names: SF3B10, SF3B5
Pfam: Splicing factor 3B subunit 10 (SF3b10)
InterPro:
Splicing factor 3B subunit 5 in PDB entry 8h7g, assembly 1, front view.
Splicing factor 3B subunit 5 in PDB entry 8h7g, assembly 1, side view.
Splicing factor 3B subunit 5 in PDB entry 8h7g, assembly 1, top view.
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Transcription factor SPT20 homolog
Chain: D
Length: 779 amino acids
Theoretical weight: 85.88 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8NEM7 (Residues: 1-779; Coverage: 100%)
Gene names: C13orf19, FAM48A, FP757, SUPT20H
Pfam: Spt20, SEP domain
InterPro:
Transcription factor SPT20 homolog in PDB entry 8h7g, assembly 1, front view.
Transcription factor SPT20 homolog in PDB entry 8h7g, assembly 1, side view.
Transcription factor SPT20 homolog in PDB entry 8h7g, assembly 1, top view.
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Transcription initiation protein SPT3 homolog
Chain: E
Length: 317 amino acids
Theoretical weight: 35.84 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O75486 (Residues: 1-317; Coverage: 100%)
Gene names: SPT3, SUPT3H
Pfam: Transcription initiation factor IID, 18kD subunit
InterPro:
Transcription initiation protein SPT3 homolog in PDB entry 8h7g, assembly 1, front view.
Transcription initiation protein SPT3 homolog in PDB entry 8h7g, assembly 1, side view.
Transcription initiation protein SPT3 homolog in PDB entry 8h7g, assembly 1, top view.
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Transcriptional adapter 1
Chain: G
Length: 374 amino acids
Theoretical weight: 41.8 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q96BN2 (Residues: 1-335; Coverage: 100%)
Gene names: TADA1, TADA1L
Pfam: Transcriptional regulator of RNA polII, SAGA, subunit
InterPro: Transcriptional coactivator Hfi1/Transcriptional adapter 1
Transcriptional adapter 1 in PDB entry 8h7g, assembly 1, front view.
Transcriptional adapter 1 in PDB entry 8h7g, assembly 1, side view.
Transcriptional adapter 1 in PDB entry 8h7g, assembly 1, top view.
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TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
Chain: H
Length: 589 amino acids
Theoretical weight: 66.22 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O75529 (Residues: 1-589; Coverage: 100%)
Gene names: PAF65B, TAF5L
Pfam:
InterPro:
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L in PDB entry 8h7g, assembly 1, front view.
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L in PDB entry 8h7g, assembly 1, side view.
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L in PDB entry 8h7g, assembly 1, top view.
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STAGA complex 65 subunit gamma
Chain: I
Length: 455 amino acids
Theoretical weight: 50.71 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O94864 (Residues: 1-414; Coverage: 100%)
Gene names: KIAA0764, SUPT7L
Pfam: Bromodomain associated
InterPro:
STAGA complex 65 subunit gamma in PDB entry 8h7g, assembly 1, front view.
STAGA complex 65 subunit gamma in PDB entry 8h7g, assembly 1, side view.
STAGA complex 65 subunit gamma in PDB entry 8h7g, assembly 1, top view.
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TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
Chain: K
Length: 622 amino acids
Theoretical weight: 67.9 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y6J9 (Residues: 1-622; Coverage: 100%)
Gene names: PAF65A, TAF6L
Pfam:
InterPro:
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L in PDB entry 8h7g, assembly 1, front view.
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L in PDB entry 8h7g, assembly 1, side view.
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L in PDB entry 8h7g, assembly 1, top view.
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Transcription initiation factor TFIID subunit 9
Chain: M
Length: 264 amino acids
Theoretical weight: 29.01 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q16594 (Residues: 1-264; Coverage: 100%)
Gene names: TAF2G, TAF9, TAFII31
Pfam: Transcription initiation factor IID, 31kD subunit
InterPro:
Transcription initiation factor TFIID subunit 9 in PDB entry 8h7g, assembly 1, front view.
Transcription initiation factor TFIID subunit 9 in PDB entry 8h7g, assembly 1, side view.
Transcription initiation factor TFIID subunit 9 in PDB entry 8h7g, assembly 1, top view.
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Transcription initiation factor TFIID subunit 10
Chain: O
Length: 218 amino acids
Theoretical weight: 21.73 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q12962 (Residues: 1-218; Coverage: 100%)
Gene names: TAF10, TAF2A, TAF2H, TAFII30
Pfam: Transcription initiation factor TFIID 23-30kDa subunit
InterPro: Transcription initiation factor TFIID, 23-30kDa subunit
Transcription initiation factor TFIID subunit 10 in PDB entry 8h7g, assembly 1, front view.
Transcription initiation factor TFIID subunit 10 in PDB entry 8h7g, assembly 1, side view.
Transcription initiation factor TFIID subunit 10 in PDB entry 8h7g, assembly 1, top view.
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Transcription initiation factor TFIID subunit 12
Chain: R
Length: 161 amino acids
Theoretical weight: 17.95 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q16514 (Residues: 1-161; Coverage: 100%)
Gene names: TAF12, TAF15, TAF2J, TAFII20
Pfam: Transcription initiation factor TFIID subunit A
InterPro:
Transcription initiation factor TFIID subunit 12 in PDB entry 8h7g, assembly 1, front view.
Transcription initiation factor TFIID subunit 12 in PDB entry 8h7g, assembly 1, side view.
Transcription initiation factor TFIID subunit 12 in PDB entry 8h7g, assembly 1, top view.
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Unassigned sequence
Chain: X
Length: 19 amino acids
Theoretical weight: 1.64 KDa
Source organism: Homo sapiens
Unassigned sequence in PDB entry 8h7g, assembly 1, front view.
Unassigned sequence in PDB entry 8h7g, assembly 1, side view.
Unassigned sequence in PDB entry 8h7g, assembly 1, top view.
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Ataxin-7
Chain: L
Length: 892 amino acids
Theoretical weight: 95.6 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O15265 (Residues: 1-892; Coverage: 100%)
Gene names: ATXN7, SCA7
Pfam: SCA7, zinc-binding domain
InterPro: SCA7 domain
Ataxin-7 in PDB entry 8h7g, assembly 1, front view.
Ataxin-7 in PDB entry 8h7g, assembly 1, side view.
Ataxin-7 in PDB entry 8h7g, assembly 1, top view.
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