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Crystal structure of pro-interleukin-18 and caspase-4 complex

X-ray diffraction
3.12Å resolution
PDB entry 8j6k coloured by chain, front view.
PDB entry 8j6k coloured by chain, side view.
PDB entry 8j6k coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 25428.32 Å2
Buried surface area: 8587.14 Å2
Dissociation area: 562.05 Å2
Dissociation energy (ΔGdiss): -8.04 kcal/mol
Dissociation entropy (TΔSdiss): 12.25 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-235982

Macromolecules

Caspase-4 subunit p20
Chain: A
Length: 169 amino acids
Theoretical weight: 19.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P49662 (Residues: 102-270; Coverage: 45%)
Gene names: CASP4, ICH2
Pfam: Caspase domain
Caspase-4 subunit p20 in PDB entry 8j6k, assembly 1, front view.
Caspase-4 subunit p20 in PDB entry 8j6k, assembly 1, side view.
Caspase-4 subunit p20 in PDB entry 8j6k, assembly 1, top view.
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Caspase-4 subunit p10
Chain: a
Length: 88 amino acids
Theoretical weight: 10.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P49662 (Residues: 290-377; Coverage: 23%)
Gene names: CASP4, ICH2
Pfam: Caspase domain
Caspase-4 subunit p10 in PDB entry 8j6k, assembly 1, front view.
Caspase-4 subunit p10 in PDB entry 8j6k, assembly 1, side view.
Caspase-4 subunit p10 in PDB entry 8j6k, assembly 1, top view.
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Interleukin-18
Chain: B
Length: 194 amino acids
Theoretical weight: 22.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q14116 (Residues: 1-193; Coverage: 100%)
Gene names: IGIF, IL18, IL1F4
Pfam: Interleukin-1 / 18
Interleukin-18 in PDB entry 8j6k, assembly 1, front view.
Interleukin-18 in PDB entry 8j6k, assembly 1, side view.
Interleukin-18 in PDB entry 8j6k, assembly 1, top view.
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Arginine ADP-riboxanase OspC3
Chain: C
Length: 161 amino acids
Theoretical weight: 18.37 KDa
Source organism: Shigella flexneri
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A0A0H2US87 (Residues: 332-484; Coverage: 32%)
Gene names: SF_p0115, ospC3
Pfam: Shigella flexneri OspC protein
Arginine ADP-riboxanase OspC3 in PDB entry 8j6k, assembly 1, front view.
Arginine ADP-riboxanase OspC3 in PDB entry 8j6k, assembly 1, side view.
Arginine ADP-riboxanase OspC3 in PDB entry 8j6k, assembly 1, top view.
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