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Crystal structure of C/EBPbeta BZIP domain bound to a high affinity DNA

X-ray diffraction
2.2Å resolution
PDB entry 8k8d coloured by chain, front view.
PDB entry 8k8d coloured by chain, side view.
PDB entry 8k8d coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule
1 distinct DNA molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: bZIP transcription factor complex, CEBPB-CEBPB and DNA
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Multimeric state: hetero tetramer
Accessible surface area: 14456.75 Å2
Buried surface area: 5151.94 Å2
Dissociation area: 2,031.41 Å2
Dissociation energy (ΔGdiss): 24.55 kcal/mol
Dissociation entropy (TΔSdiss): 21.91 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-240739

Macromolecules

CCAAT/enhancer-binding protein beta
Chains: A, B
Length: 79 amino acids
Theoretical weight: 9.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P17676 (Residues: 259-336; Coverage: 23%)
Gene names: CEBPB, PP9092, TCF5
Pfam: Basic region leucine zipper
CCAAT/enhancer-binding protein beta in PDB entry 8k8d, assembly 1, front view.
CCAAT/enhancer-binding protein beta in PDB entry 8k8d, assembly 1, side view.
CCAAT/enhancer-binding protein beta in PDB entry 8k8d, assembly 1, top view.
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DNA chains C, D
Name: DNA (5'-D(*CP*AP*TP*TP*AP*CP*GP*TP*AP*AP*TP*G)-3')
Representative chains: C, D
Source organism: synthetic construct [32630]
Expression system: Not provided
Length: 12 nucleotides
Theoretical weight: 3.66 KDa
DNA (5'-D(*CP*AP*TP*TP*AP*CP*GP*TP*AP*AP*TP*G)-3') in PDB entry 8k8d, assembly 1, front view.
DNA (5'-D(*CP*AP*TP*TP*AP*CP*GP*TP*AP*AP*TP*G)-3') in PDB entry 8k8d, assembly 1, side view.
DNA (5'-D(*CP*AP*TP*TP*AP*CP*GP*TP*AP*AP*TP*G)-3') in PDB entry 8k8d, assembly 1, top view.
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