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Structure of 5D3-Fab and nanobody(Nb96)-bound ABCG2

Electron Microscopy
3.49Å resolution
PDB entry 8p8j coloured by chain, front view.
PDB entry 8p8j coloured by chain, side view.
PDB entry 8p8j coloured by chain, top view.
Source organisms:
Assembly composition:
hetero heptamer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Broad substrate specificity ATP-binding cassette transporter ABCG2 and IG-light kappa chain and IG-heavy chain and IG-heavy chain
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Multimeric state: hetero heptamer
Accessible surface area: 68727.15 Å2
Buried surface area: 13892.24 Å2
Dissociation area: 1,090.84 Å2
Dissociation energy (ΔGdiss): -1.36 kcal/mol
Dissociation entropy (TΔSdiss): 12.1 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-227952

Macromolecules

Broad substrate specificity ATP-binding cassette transporter ABCG2
Chains: A, B
Length: 655 amino acids
Theoretical weight: 72.39 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UNQ0 (Residues: 1-655; Coverage: 100%)
Gene names: ABCG2, ABCP, BCRP, BCRP1, MXR
Pfam:
Broad substrate specificity ATP-binding cassette transporter ABCG2 in PDB entry 8p8j, assembly 1, front view.
Broad substrate specificity ATP-binding cassette transporter ABCG2 in PDB entry 8p8j, assembly 1, side view.
Broad substrate specificity ATP-binding cassette transporter ABCG2 in PDB entry 8p8j, assembly 1, top view.
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5D3(Fab) light chain variable domain
Chains: C, E
Length: 214 amino acids
Theoretical weight: 23.59 KDa
Source organism: Mus musculus
Expression system: Mus musculus
5D3(Fab) light chain variable domain in PDB entry 8p8j, assembly 1, front view.
5D3(Fab) light chain variable domain in PDB entry 8p8j, assembly 1, side view.
5D3(Fab) light chain variable domain in PDB entry 8p8j, assembly 1, top view.
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5D3(Fab) heavy chain variable domain
Chains: D, F
Length: 221 amino acids
Theoretical weight: 23.84 KDa
Source organism: Mus musculus
Expression system: Mus musculus
5D3(Fab) heavy chain variable domain in PDB entry 8p8j, assembly 1, front view.
5D3(Fab) heavy chain variable domain in PDB entry 8p8j, assembly 1, side view.
5D3(Fab) heavy chain variable domain in PDB entry 8p8j, assembly 1, top view.
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Nanobody
Chain: Z
Length: 125 amino acids
Theoretical weight: 13.7 KDa
Source organism: Lama glama
Expression system: Escherichia coli
Nanobody in PDB entry 8p8j, assembly 1, front view.
Nanobody in PDB entry 8p8j, assembly 1, side view.
Nanobody in PDB entry 8p8j, assembly 1, top view.
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