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Structure of the murine trace amine-associated receptor TAAR7f bound to N,N-dimethylcyclohexylamine (DMCH) in complex with mini-Gs trimeric G protein

Electron Microscopy
2.92Å resolution
PDB entry 8pm2 coloured by chain, front view.
PDB entry 8pm2 coloured by chain, side view.
PDB entry 8pm2 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero pentamer (preferred)
Entry contents: 5 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentamer
Accessible surface area: 41664.63 Å2
Buried surface area: 11412.68 Å2
Dissociation area: 1,209.45 Å2
Dissociation energy (ΔGdiss): 1.52 kcal/mol
Dissociation entropy (TΔSdiss): 12.51 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-239132

Macromolecules

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Chain: A
Length: 249 amino acids
Theoretical weight: 28.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P63092 (Residues: 5-394; Coverage: 63%)
  • Best match: P63092-2 (Residues: 5-380)
Gene names: GNAS, GNAS1, GSP
Pfam: G-protein alpha subunit
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short in PDB entry 8pm2, assembly 1, front view.
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short in PDB entry 8pm2, assembly 1, side view.
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short in PDB entry 8pm2, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Chain: B
Length: 340 amino acids
Theoretical weight: 37.34 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P62873 (Residues: 2-340; Coverage: 100%)
Gene name: GNB1
Pfam: WD domain, G-beta repeat
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 8pm2, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 8pm2, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 8pm2, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Chain: G
Length: 71 amino acids
Theoretical weight: 7.85 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P59768 (Residues: 1-71; Coverage: 100%)
Gene name: GNG2
Pfam: GGL domain
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 8pm2, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 8pm2, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 8pm2, assembly 1, top view.
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Nanobody 35
Chain: N
Length: 156 amino acids
Theoretical weight: 16.93 KDa
Source organism: Lama glama
Expression system: Escherichia coli BL21
Nanobody 35 in PDB entry 8pm2, assembly 1, front view.
Nanobody 35 in PDB entry 8pm2, assembly 1, side view.
Nanobody 35 in PDB entry 8pm2, assembly 1, top view.
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Trace amine-associated receptor 7f
Chain: R
Length: 365 amino acids
Theoretical weight: 41.01 KDa
Source organism: Mus musculus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q5QD08 (Residues: 1-358; Coverage: 100%)
Gene name: Taar7f
Pfam: 7 transmembrane receptor (rhodopsin family)
Trace amine-associated receptor 7f in PDB entry 8pm2, assembly 1, front view.
Trace amine-associated receptor 7f in PDB entry 8pm2, assembly 1, side view.
Trace amine-associated receptor 7f in PDB entry 8pm2, assembly 1, top view.
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