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Comparison of room-temperature and cryogenic structures of soluble Epoxide Hydrolase with ligands bound.

X-ray diffraction
2.24Å resolution
PDB entry 8qvh coloured by chain, front view.
PDB entry 8qvh coloured by chain, side view.
PDB entry 8qvh coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Bifunctional epoxide hydrolase 2
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Multimeric state: homo dimer
Accessible surface area: 43071.08 Å2
Buried surface area: 4364.53 Å2
Dissociation area: 2,182.26 Å2
Dissociation energy (ΔGdiss): 7.56 kcal/mol
Dissociation entropy (TΔSdiss): 15.51 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-152745

Macromolecules

Bifunctional epoxide hydrolase 2
Chain: A
Length: 549 amino acids
Theoretical weight: 62 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P34913 (Residues: 1-548; Coverage: 99%)
Gene name: EPHX2
Pfam:
Bifunctional epoxide hydrolase 2 in PDB entry 8qvh, assembly 1, front view.
Bifunctional epoxide hydrolase 2 in PDB entry 8qvh, assembly 1, side view.
Bifunctional epoxide hydrolase 2 in PDB entry 8qvh, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P34913  
154950100150200250300350400450500
 
200400
UniProt
P34913
Chains
Secondary structure
Ligand binding sites
Interaction interfaces
Sequence conservation
Molecule details ›

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