› 8ss2

Electron Microscopy
3.58Å resolution

Structure of AMPA receptor GluA2 complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to competitive antagonist ZK and channel blocker spermidine (closed state)

Released:
DOI: 10.2210/pdb8ss2/pdb
PDB entry 8ss2 coloured by chain, front view.
PDB entry 8ss2 coloured by chain, side view.
PDB entry 8ss2 coloured by chain, top view.
Source organisms:
Primary publication:
Modulation of GluA2-γ5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2.
Gangwar SP, Yen LY, Yelshanskaya MV, Korman A, Jones DR, Sobolevsky AI
OpenAccess logo Nat Struct Mol Biol (2023)
PMID: 37653241
Related structures: EMD-40741

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-228100 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Glutamate receptor 2; Voltage-dependent calcium channel gamma-5 subunit Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1026 amino acids
Theoretical weight: 114.98 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: P19491 (Residues: 25-847; Coverage: 95%)
  • Canonical: Q8VHW8 (Residues: 4-207; Coverage: 74%)
Gene names: Cacng5, GluA2, Glur2, Gria2
Sequence domains:
Protein cornichon homolog 2 Chains: E, F
Molecule details ›
Chains: E, F
Length: 160 amino acids
Theoretical weight: 18.95 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6PI25 (Residues: 1-160; Coverage: 100%)
Gene names: CNIH2, CNIL
Sequence domains: Cornichon protein

Ligands and Environments

5 bound ligands:
Ligand ZK1 4 x ZK1
Ligand PCW 26 x PCW
Ligand CLR 2 x CLR
Ligand AJP 2 x AJP
Ligand SPD 1 x SPD
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.58Å
Relevant EMDB volumes: EMD-40741
Expression system: Homo sapiens

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