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Structure of AMPA receptor GluA2 complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to competitive antagonist ZK and channel blocker spermidine (closed state)

Electron Microscopy
3.58Å resolution
PDB entry 8ss2 coloured by chain, front view.
PDB entry 8ss2 coloured by chain, side view.
PDB entry 8ss2 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero hexamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Protein cornichon homolog 2 and Glutamate receptor 2, Voltage-dependent calcium channel gamma-5 subunit
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Multimeric state: hetero hexamer
Accessible surface area: 162701.92 Å2
Buried surface area: 57581.31 Å2
Dissociation area: 2,961.73 Å2
Dissociation energy (ΔGdiss): 49.01 kcal/mol
Dissociation entropy (TΔSdiss): 26.92 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-228100

Macromolecules

Glutamate receptor 2; Voltage-dependent calcium channel gamma-5 subunit
Chains: A, B, C, D
Length: 1026 amino acids
Theoretical weight: 114.98 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: P19491 (Residues: 25-847; Coverage: 95%)
  • Canonical: Q8VHW8 (Residues: 4-207; Coverage: 74%)
    • nullnull
Gene names: Cacng5, GluA2, Glur2, Gria2
Pfam:
Glutamate receptor 2 in PDB entry 8ss2, assembly 1, front view.
Glutamate receptor 2 in PDB entry 8ss2, assembly 1, side view.
Glutamate receptor 2 in PDB entry 8ss2, assembly 1, top view.
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Protein cornichon homolog 2
Chains: E, F
Length: 160 amino acids
Theoretical weight: 18.95 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6PI25 (Residues: 1-160; Coverage: 100%)
Gene names: CNIH2, CNIL
Pfam: Cornichon protein
Protein cornichon homolog 2 in PDB entry 8ss2, assembly 1, front view.
Protein cornichon homolog 2 in PDB entry 8ss2, assembly 1, side view.
Protein cornichon homolog 2 in PDB entry 8ss2, assembly 1, top view.
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